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New Twin-Screw Granulator Helps Maximize Throughput in Continuous Drug Manufacturing

Thermo Fisher Scientific

Thermo Scientific Pharma 24 TSG twin-screw granulator helps pharmaceutical companies easily transition from batch to continuous manufacturing

26 Jun 2018
Aidan Barry
Administrator / Office Personnel

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Pharmaceutical companies, contract research organizations and contract manufacturing organizations who produce oral solid dosage (OSD) forms can benefit from a new twin-screw granulator (TSG) designed to maximize productivity and accelerate continuous manufacturing.

The Thermo Scientific Pharma 24 TSG twin-screw granulator can be integrated into a continuous production line, or used as a standalone instrument for project development or small-scale production. It easily adapts to most manufacturing environments, including explosive areas, and its modular screw design provides the flexibility to granulate even challenging formulations. The Pharma 24 TSG system is designed for twin-screw granulation, resulting in fast cleaning cycles, minimal maintenance requirements and high machine uptime, all of which are essential for continuous manufacturing.

“Twin-screw granulation has emerged as a promising technique to support the growing pharmaceutical industry shift toward continuous manufacturing,” said Hanna Granö-Fabritius, senior business director, materials characterization for Thermo Fisher Scientific. “As drug developers adopt advanced technology for continuous manufacturing, they are increasing yields and becoming more responsive to market demands.”

Additional benefits of the Thermo Scientific Pharma 24 TSG twin-screw granulator for continuous manufacturing include:
• A throughput rate of up to 70 kg/h;
• A length/diameter ratio of 40:1 that offers flexible adaptation for processing length, screw setup and introduction of ingredients into the process;
• Long running times to facilitate adequate drug supply when faced with rising demands;
• Minimal downtime for cleaning that may result in 24/7 production and higher productivity; and
• Permanent online monitoring to facilitate detection of substandard products and discard them from the process in real-time.

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Process ChemistryProcess chemistry is an important stage of drug development for scaling-up drug production or chemical synthesis reactions. It is useful for optimizing economical and efficient drug production. Process chemistry uses reactors and pump systems as well as reagents, standards and buffers.Scale-upScale-Up is generally defined as the process of transferring the results of the discovery phases of the drug discovery process, obtained on a laboratory scale, to the pilot plant and finally to production scale. Scale-Up uses reactors and pump systems as well as reagents, standards and buffers. Often Scale-Up is provided as a service by Contract Manufacturing Organizations (CMOs). Bioprocessing / FermentationBioprocessing is the use of biological materials to perform commercial, scientific or medical research processes. Biological materials used include cells, enzymes and organisms. Usually bioprocessing requires a batch or continuous bioreactor such as a fermentor or cell culture system. The advantages of using a reactor include high productivity, easy configuration, adjustable values and automation.AutomationAutomation in laboratories and manufacturing processes enhances efficiency, precision, and scalability by reducing the need for manual intervention. It plays a critical role in improving productivity, minimizing human error, and accelerating workflows in fields like diagnostics, drug development, and industrial testing. Automation technologies include robotic systems, automated liquid handlers, and process control systems that streamline complex tasks and ensure consistent, reproducible results. Explore our peer-reviewed product directory to discover the best automation solutions, compare options, read user reviews, and get prices directly from manufacturers.Process OptimizationProcess optimization involves improving the efficiency, cost-effectiveness, and quality of processes in various industries, including manufacturing, pharmaceuticals, and biotechnology. Explore process optimization solutions in our peer-reviewed product directory; compare products, check reviews, and get pricing directly from manufacturers.PharmaceuticalsPharmaceuticals are medicinal drugs used in healthcare to diagnose, prevent, cure and treat illnesses. Pharmaceuticals that are excreted after use appear in wastewater and can have detrimental effects on the environment.Sample ProcessingSample processing is required to prepare samples prior to analysis. Technologies used for sample processing include homogenizers, grinders, mills and mixers.ManufacturingManufacturing is the production of merchandise for use or sale using labor and machines, tools, chemical and biological processing, or formulation.

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New Twin-Screw Granulator Helps Maximize Throughput in Continuous Drug Manufacturing