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New System Screens More Clones in Less Time

Molecular Devices®
24 Jan 2011
Sarah Sarah
Marketing / Sales

Product news

The new ClonePix™2 system from Genetix Ltd. utilizes fluorescence and white light imaging and advanced image analysis capabilities to automatically screen more clones in less time, select cells with optimal expression levels and pick colonies with accuracy and confidence.

The original ClonePix FL systems are used in over one hundred biopharmaceutical organizations and research laboratories to provide faster, more productive workflows than conventional techniques. Often employed to reduce cell line/antibody development times, data from these systems are cited increasingly in scientific literature and at conferences, an indication of acceptance within the industry. The most frequently applied approach to monitor expression levels takes advantage of specific chemistries developed by Genetix to enable label-free quantification of secreted proteins – a significant advantage when screening and selecting cell lines for production of biotherapeutics, such as monoclonal antibodies.

Dr. Mark Truesdale, Marketing Manager at Genetix, explained the reasoning behind the development of a second generation instrument: “Working closely with our existing customers has enabled us to specify software and hardware enhancements to raise overall performance. Imaging analysis software has been enhanced to improve consistency when ranking clones. A redesign of robotics has reduced the number of plate handling steps, thereby minimizing the risk of colony disturbance or contamination and giving greater picking accuracy. We believe that ClonePix 2 users will experience a smoother, more efficient workflow.”
ClonePix 2 will be showcased on the Genetix booths at Lab Automation 2011 in Palm Springs and ABRF 2011 in San Antonio, Texas.

Upcoming webinar
Those interested in learning more about the use of ClonePix systems in the biopharmaceutical industry can listen online to Jolanda Gerritsen, Technology Expert, Cell Line Development at Genmab in The Netherlands: Optimal selection of monoclonal cell lines producing high amounts of biopharmaceutical human IgGs

Dr. Gerritsen will describe how Genmab have developed a state-of-the-art cell line development process for the generation of CHO cell lines expressing therapeutic IgGs by optimizing and integrating emerging technologies.

The webinar will take place on February 9 at 17:30 CET, 16:30 GMT, 11:30 AM EST, 8:30 AM PST. Follow the 'Company article page link' top right of this page to register.

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High-Throughput ScreeningHigh-throughput screening (HTS) is an automated drug discovery technique for identification of active compounds against a compound library. Use HTS readers and integrated assay preparation / analysis workstations to screen your compounds. Identify active compounds against various HTS libraries, including membranes, proteins and peptides and HTS cell lines. Find the best high-throughput screening products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Cell Lines Stem Cells and Primary CellsPrimary cell cultures, established cell lines and stem cells are vital for <i>in vitro</i> and <i>ex vivo</i> experimentation. High-quality cells, optimized for your applications, alongside optimized cell substrates, growth medium and supplements, are critical for experimental success. Explore a range of cells suitable for your applications, including isogenic cell lines, competent cells, induced pluripotent stem cell (iPSC)-derived cell lines, fungal/bacterial/mammalian cell lines, stem cells and cancer cell lines. Find the best cells for your research in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Assay AssemblyAssay Assembly is technique used in drug discovery to develop assays to test the cytotoxicity, genotoxicity, or other activities of a compound on a cell. Assay assembly requires chip assembly, a delivery system and a detection and analysis method. Beneficial features of assay kits or automated systems include high-throughput, high speed and sensitivity and low signal to noise ratio.Cell-Based AssaysCell-based assays are used to monitor the presence, quantity and activities of a desired cellular analyte including drug molecules or biomarkers. This can reveal information on cell health (apoptosis, cytotoxicity, viability and proliferation assays), cell metabolism, cell migration and cell signaling mechanisms. Find the best cell-based assay products, kits and equipment with our peer reviewed product directory: compare products, check customer reviews and receiving pricing direct from manufacturers.High-Content ScreeningHigh-content screening (HCS), also known as high-content analysis (HCA), is a high-throughput technique used in drug discovery to identify substances that alter the phenotype of cells. HCS uses fluorescent microscopic imaging and automated image analysis to investigate cellular events such as apoptosis, cell viability, GPCR activation, oxide production, neurite outgrowth, and cell signaling. Find the best fluorescent labeling reagents, cellular assays, and high-content imaging systems in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Biopharmaceutical AdvancesBiopharmaceutical advances follow the development of pharmaceuticals derived from biotechnology, also known as biotechnology medicines. Biopharmaceuticals may be produced from cell lines, plants, or microbial cells. Important considerations of biopharmaceutical use include application, cost, production process and purification.

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New System Screens More Clones in Less Time