New Single-Use Pall® XRS 20 Bioreactor System Enhances Cell Culture Performance in Biotechnology Applications

Pall Corporation, a global leader in filtration, separation and purification, today introduced the XRS 20 Bioreactor System, a new bioreactor with unique agitation properties that incorporates a single-use, easy-to-use Allegro™ 3D biocontainer. This next generation ‘rocker’ bioreactor, designed for cultivation of mammalian cells in suspension culture, is equally suitable for applications ranging from general life sciences research to seed train operations and full Good Manufacturing Practice (GMP) production at the 2-to-20 liter scale.

The XRS 20 System’s unique bi-axial agitation promotes better mixing and higher mass transfer, which expedites transport of nutrients and metabolites in the cellular micro-environment. This allows cultures to reach higher densities with overall greater viabilities, leading to significantly higher protein expression levels.

To ensure operational simplicity, the system includes the following features:
• Allegro XRS 20 biocontainer with integrated components (sensors, filters, drain and tubing sets) for rapid installation and efficient harvesting
• Advanced XRS 20 controller with touchscreen interface for easy monitoring and control of process parameters
A fully enclosed XRS 20 platform with interlock provides operator safety while protecting sensitive media components from light.

“The versatile, easy-to-use XRS 20 Bioreactor System combines state-of-the-art, single-use technology with advanced controls and features that improve cell culture performance,” said Ken Frank, President, Pall BioPharmaceuticals.