New Screening Library Offers Exceptional Chemical Diversity to Increase Hit Probability
25 Jun 2014
Product news
A new highly diverse library of screening compounds is designed to maximize efficiency and productivity for researchers in early phase small molecule drug discovery.
By delivering exceptionally diverse coverage of the space spanned by all possible drug-like molecules and associated characteristics, the Maybridge HitCreator library provides a greater hit probability than larger, but less diverse, screening libraries.
The Maybridge HitCreator library consists of 14,000 screening compounds selected for maximum diversity by rigorous analysis of more than 500,000 commercially available screening compounds. Each Maybridge HitCreator diversity library is conveniently available off the shelf and supplied as dry films in Thermo Scientific Matrix 96 shallow-well plates or 384-well microplates.
“Diversity-based screening is a vital tool for discovering new molecules that could potentially influence drug discovery. However, the wide range of commercially available screening libraries is daunting for scientists to pick the ideal library for their specific requirements,” said Simon Pearce, product marketing manager, Global Chemicals, Thermo Fisher Scientific. “Our new Maybridge HitCreator library simplifies this challenge through its exceptional diversity. It removed the need to choose between different libraries and covers all drug-like chemical space to provide cost effective hit reliability from a single library.”
Building on more than 50 years in designing proven libraries, all compounds within the Maybridge HitCreator are meticulously selected for a high hit probability. All are drug-like and conform to Lipinski’s “Rule of Five”, ensuring they possess key physicochemical properties frequently found in orally active drugs, as well as additional filters. These include optimization to ensure a drug can readily permeate cells, therefore HitCreator compounds are selected to have a Polar Surface Area (PSA) of ≤ 140Å2. In addition, all compounds have been screened to remove inappropriate chemical structures, reducing the chance of “false hits.”
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Maybridge Screening Collection
Thermo Fisher ScientificThe Maybridge Screening collection consists of over 53,000 organic compounds, largely produced by us at Maybridge. These are individually designed compounds, produced by innovative synthetic techniques, based on over 45 years of experience in heterocyclic chemistry. The pre-plated HitFinder™ Collection consists of 14,400 Maybridge Screening Compounds, selected to represent the diversity of the Maybridge Screening Collection using a clustering algorithm based on standard Daylight Fingerprints and Tanimoto similarity, and is conveniently supplied as dry films in Matrix 96 shallow well plates or 384 well microplates.The compounds in the Maybridge collection generally obey Lipinski's "rule of five" and so demonstrate good ADME (absorption, distribution, metabolism and excretion) profiles, which makes them ideal candidates for development beyond the initial Screening assay.Supply formats: In 96 well plates at mass >=2µmol or >=0.5mg as powder, dry films or frozen DMSO solutions In 96 or 384 well plates at mass > 0.1µmol or >0.01mg as dry films or frozen DMSO solutions. In vials at mass >2µmol or 0.5mg as powder or DMSO solutions.