NewsSeparations
New Resin for the Capture and Large-Scale Purification of Monoclonal Antibodies
14 Oct 2010Sarah Sarah
Marketing / Sales
Product news
Tosoh Bioscience LLC introduces Toyopearl AF-rProtein A-650F resin for the capture and large-scale purification of monoclonal antibodies. This resin contains an alkaline resistant recombinant Protein A variant bound to the resin by multipoint attachment.
The Toyopearl AF-rProtein A-650F resin is synthesized using a novel recombinant Protein A ligand bound to the 45 micron, 1,000Å pore size base bead, using multipoint attachment. The ligand is non-animal derived. The new resin can tolerate CIP in both 0.1mol/L and 0.5mol/L NaOH.
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Sample PreparationSample preparation can improve the quality and speed of separation techniques. Products to assist sample preparation include filtration equipment, evaporators, membranes and sieves.AntibodiesAntibodies are used in techniques such as confocal and fluorescence microscopy, flow cytometry, ELISA, ELISPOT, immunohistochemistry, western blotting and immunopreciptation. Select specific antigen reactivity, high specific affinity, low non-specific binding, monoclonal or polyclonal, primary or secondary antibodies and associated conjugates such as an enzyme or dye for visualization.ProteomicsProteomics is the systemic bioinformatics study of proteins and amino acids, including their structure, size, function and identification. Tools used in proteomics include chromatography, blotting and gels, protein arrays, mass spectrometry and ELISA and associated analysis software. Analyzers and proteomic systems should be sensitive, high resolution, fast and may be automated for high-throughput.