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New Raptor™ FluoroPhenyl Phase: the Power of HILIC and RP Modes in One LC Column

Restek Corp.

Restek’s new Raptor™ FluoroPhenyl Phase combines the speed of superficially porous particles with the resolution of highly selective USLC® technology

21 Dec 2015
Weylan Kiam-Laine
Microbiologist

Product news

Restek has now extended the speed and reliability of Raptor™ column technology into the HILIC realm with the addition of Raptor™ FluoroPhenyl columns. Restek’s Raptor™ FluoroPhenyl phase offers chromatographers the ability to run in reversed-phase or HILIC mode for a variety of compounds. The Restek® Raptor™ FluoroPhenyl column is also amenable to LC-MS because it is extremely reliable and efficient with acidic mobile phases.

Restek chemists became the first to combine the speed of superficially porous particles (also known as SPP or “core-shell” particles) with the resolution of highly selective USLC® technology. This new breed of chromatographic column allows you to more easily achieve peak separation and faster analysis times without expensive UHPLC instrumentation.

Switch to a Raptor™ FluoroPhenyl LC column for reliable performance in both reversed-phase and HILIC modes.

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Ultra Selective Liquid Chromatography™

Restek Corp.

Reversed Phase Method Development that's Simple, Fast, Effective, and Universal!•Boasts the widest range of reversed phase selectivity in the industry.•Simplifies column selection down to 4 unique stationary phases.•Employs orthogonal selectivity to speed up effective method development.•Maximizes efficacy of your column screening systems.•Fits any HPLC or UHPLC instrumentation. Restek Ultra Selective Liquid Chromatography™ (USLC™) technology is the directed application of selectivity—the most influential factor affecting resolution—to optimize separations and improve method performance. Restek has extensively studied reversed phase selectivity, and as a result, we offer chromatographers the most effective and widest range of USLC™ stationary phase chemistries in the industry! Pinnacle® DB columns (1.9 µm) feature base deactivated silica and are recommended for scalable UHPLC and HPLC analyses. Ultra columns (3 and 5 µm) use highest purity silica and are well suited for traditional HPLC analyses. Viva columns incorporate wide pore silica, making them ideal for large-molecule biological separations using HPLC.

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UHPLC and HPLCHigh performance liquid chromatography (HPLC) and ultra high performance liquid chromatography (UHPLC), also known as UPLC, are analytical techniques used to separate, identify and quantitate components of complex mixtures including biological samples such as proteins and lipids as well as chemical mixtures of pesticides, drugs and oils. Both techniques are liquid chromatographic methods but differ by operating pressures (HPLC < 6000 psi < UHPLC ). Components of HPLC and UHPLC systems include columns, detectors, pumps, autosamplers and column heaters. Explore a range of UHPLC and HPLC columns for your specific sample needs including reverse phase, normal phase, ion exchange, HILIC, ion exclusion and size exclusion columns. For more specialized HPLC, explore FPLC, countercurrent LC and simulated moving bed systems. Find the best UHPLC and HPLC equipment in our peer reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Sample PreparationSample preparation can improve the quality and speed of separation techniques. Products to assist sample preparation include filtration equipment, evaporators, membranes and sieves.LC-MSLC-MS (liquid chromatography-mass spectrometry) systems and equipment are used for separation and quantitative analysis of complex mixtures, combining liquid chromatography and mass spectrometry. Quantify proteins, contaminants, pesticides or screen for drug metabolites with a high level of sensitivity. LC-MS systems and equipment include reverse phase, normal phase and specialized columns integrated with various MS detectors such as time-of-flight (TOF), quadrupole, orbitrap or ion trap mass analyzers. LC-MS/MS instruments equipped with a qTOF or triple quadrupole analyzer give greater sensitivity and resolving power to your analysis. Find the best LC-MS equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.ProteomicsProteomics is the systemic bioinformatics study of proteins and amino acids, including their structure, size, function and identification. Tools used in proteomics include chromatography, blotting and gels, protein arrays, mass spectrometry and ELISA and associated analysis software. Analyzers and proteomic systems should be sensitive, high resolution, fast and may be automated for high-throughput.MetabolomicsMetabolomics is the study of small metabolites (the intermediates and products of metabolism). It involves the identification and quantification of cellular metabolites using analytical technologies such as GC, HPLC, NMR, and LC/MS.HILICProteomicsProteomics refers to the analysis of proteins through a variety of different experiments in order to understand structure and functionality. Typical techniques include protein purification and mass spectrometry. Sample ProcessingSample processing is required to prepare samples prior to analysis. Technologies used for sample processing include homogenizers, grinders, mills and mixers.LC-MSLiquid Chromatography-Mass Spectrometry (LCMS) is a powerful analytical technique that combines the separation power of liquid chromatography with the detection capabilities of mass spectrometry. It is widely used for qualitative and quantitative analysis of complex mixtures in pharmaceuticals, proteomics, and environmental studies. Browse our peer-reviewed product directory to find the best LCMS systems, compare products, check reviews, and get pricing directly from manufacturers.

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New Raptor™ FluoroPhenyl Phase: the Power of HILIC and RP Modes in One LC Column