New Multimode Microplate Reader Delivers Automation, Simplicity and Versatility for Microplate Assays

10 Feb 2015
Sarah Thomas
Associate Editor

Product news

Highly intuitive software combines built-in safety and intelligence for exceptional performance

A new multimode microplate reader with highly intuitive software delivers automated and versatile functionality to bioscience researchers performing a variety of microplate assays. The Thermo Scientific Varioskan LUX multimode microplate reader with new Thermo Scientific SkanIt Software is designed to simplify data acquisition and analysis and accelerate consistency and reliability in assay results.

“The Varioskan LUX with SkanIt software builds upon our long history in pioneering microplate reader technology innovations,” said Hanna Grano-Fabritius, business director, Sample Preparation and Analysis, Thermo Fisher Scientific. “With advancements including integrated smart control technology and automatic dynamic range selection, the Varioskan LUX is designed to simplify set-up while optimizing performance to deliver exceptional usability and data reliability.”

Thermo Scientific Varioskan LUX with SkanIt Software is making its debut at SLAS2015, the 4th Annual Conference and Exhibition of the Society for Laboratory Automation and Screening, booth 423 at the Washington Convention Center in Washington, D.C.

Varioskan LUX is equipped with smart safety controls to help keep research on track. These technologies include automated plate check, built-in shaker speed control, and automatic prime check and position sensors for the built-in dispensers, which are designed to identify and notify the user of potential errors that could compromise research. The Varioskan LUX’s SkanIt software monitors and captures measurement data throughout the run to reduce the risk of wasting expensive reagents, samples and time.

Varioskan LUX also offers an innovative automatic dynamic range selection feature that eases protocol set-up by eliminating the need for users to manually adjust sensitivity settings for each assay. The instrument automatically selects the optimal reading range based on signal intensity in the well, using settings to obtain maximum sensitivity. This helps ensure that results are comparable from assay to assay—and day to day—even when a single assay exhibits very high and very low signals. Additional product features include:
• Modular design with up to five measurement technologies: absorbance, fluorescence intensity, luminescence, time-resolved fluorescence and AlphaScreen®;
• Integrated gas module: optimal conditions for cell-based assays, gas concentrations reported in session run log for traceability;
• Extensive instrument self-diagnostics and auto-calibration: functions checked at every start-up for consistent performance, auto-calibration designed to ensure consistent, comparable results from day-to-day.

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High-Throughput ScreeningHigh-throughput screening (HTS) is an automated drug discovery technique for identification of active compounds against a compound library. Use HTS readers and integrated assay preparation / analysis workstations to screen your compounds. Identify active compounds against various HTS libraries, including membranes, proteins and peptides and HTS cell lines. Find the best high-throughput screening products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Microplate Readers / DetectorsMicroplate readers are used to automate the detection and analysis of labeled or label-free components in microplates during assays or live-cell monitoring. Microplate readers are generally distinguished by their mode of detection. Types include absorbance, luminescence, fluorescence intensity, fluorescence polarization, TRF / FRET and multimode microplate readers. Microplate readers deliver a high throughput of samples by reading multiple wells simultaneously, with the 96-well format the most commonly used. As a result, microplate readers are often used in the drug discovery, bioassays, research and pharmaceutical industries for screening applications. Microplate loading can also be automated, with robotic microplate stackers to increase throughput. Find the best microplate readers in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Cell-Based AssaysCell-based assays are used to monitor the presence, quantity and activities of a desired cellular analyte including drug molecules or biomarkers. This can reveal information on cell health (apoptosis, cytotoxicity, viability and proliferation assays), cell metabolism, cell migration and cell signaling mechanisms. Find the best cell-based assay products, kits and equipment with our peer reviewed product directory: compare products, check customer reviews and receiving pricing direct from manufacturers.High-Content ScreeningHigh-content screening (HCS), also known as high-content analysis (HCA), is a high-throughput technique used in drug discovery to identify substances that alter the phenotype of cells. HCS uses fluorescent microscopic imaging and automated image analysis to investigate cellular events such as apoptosis, cell viability, GPCR activation, oxide production, neurite outgrowth, and cell signaling. Find the best fluorescent labeling reagents, cellular assays, and high-content imaging systems in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.SLASThe Society for Laboratory Automation and Screening (SLAS) is an organization focused on laboratory automation, high-throughput screening, and biotechnology innovation. SLAS promotes scientific advancements through conferences, publications, and industry collaborations.