New Monolithic Capillary Columns Deliver High Efficiency for Biomarker Research
27 Jan 2009Product news
Phenomenex Inc., a global leader in the manufacture of separation science consumables, announces the addition of six new offerings in its Onyx™ monolithic HPLC column line, including a 150 X 0.05 mm ID choice for proteomics research. This column is optimized for the low flow-rate systems commonly used for LC/MS proteomics analysis and delivers high sensitivity for biomarker discovery.
Other new Onyx column sizes include a 0.2 mm C18 column for higher flow rates, a 150 X .2 mm trapping column, a 150 x .1 C8 column and two ultra-high-resolution C18 columns at 100 and 200 micron IDs.
The permeable Onyx media separates viscous biological samples that clog traditional columns. These columns contain solid rods of fused silica and eliminate packing issues associated with particulate media. Run times are as much as 50 percent faster than with traditional columns.
“Phenomenex has a large customer base in proteomics research where ultra-low flow rates present unique challenges,” said Terrell Mathews, strategic product manager for Phenomenex. “Our new capillary-scale monolith columns deliver some exciting new capabilities to this market.”
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Onyx Monolithic LC Columns
Phenomenex IncAcheive Faster HPLCOnyx monolithic silica-based HPLC columns are designed for high-throughput analysis and the direct injection of dirty or viscous samples. Reduce run times with extremely high flow rates (up to 9 mL/min) "Dilute-and-Shoot” dirty biological samples Scalable from capillary to semi-prep column dimensions Onyx columns deliver high efficiency separations and can be coupled together in series to produce the extreme plate counts needed to separate very complex mixtures.Dilute & Shoot Complex mixtures coupled with dirty matrices, such as serum samples encountered in the pharmaceutical/biotechnology industry, are quite difficult and time-consuming to analyze. With Onyx however, you have the option to dilute-and-shoot your sample directly onto the column because it won't clog due to the macroporous system or cause high backpressures. Flow Rate Flexibility Another unique feature is the ability to use flow rate as parameter for optimizing separations. Onyx columns are responsive to changes in flow rate and can be changed mid run to reduce total run time when certain compounds elute much later. This type of flow rate flexibility gives many options for optimization.