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New Monoclonal Antibody HPLC Columns from Thermo Fisher Scientific

Thermo Fisher Scientific
4 Feb 2015

Product news

Laboratories characterizing monoclonal antibodies (mAb) now have additional hydrophobic interaction chromatography (HIC) selectivity options, thanks to the expanded family of Thermo Scientific MAbPac HIC HPLC columns.

New Thermo Scientific MAbPac HIC-20 and MAbPac HIC-Butyl columns join the company's line of columns for monoclonal antibody analysis, a response to customer demand for additional selectivity options for characterizing mAb oxidation variants, intact mAbs, mAb aggregates or fragments and antibody drug conjugates (ADCs).

The proprietary chemistry used in the new columns is designed to provide new selectivity in high-resolution separations with excellent biocompatibility and high recovery. The columns are also designed for compatibility with organic solvent and aqueous mobile phase, as well as for rugged stability and very low carry-over.

"Our customers have been achieving excellent results analyzing proteins for years with our ProPac HIC-10 columns," said Ilze Birznieks, product line manager, biocolumns, Thermo Fisher Scientific. "Our R&D team worked with our customers to engineer these new columns, building on our experience to meet their need for analyzing increasingly complex samples".

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UHPLC and HPLCHigh performance liquid chromatography (HPLC) and ultra high performance liquid chromatography (UHPLC), also known as UPLC, are analytical techniques used to separate, identify and quantitate components of complex mixtures including biological samples such as proteins and lipids as well as chemical mixtures of pesticides, drugs and oils. Both techniques are liquid chromatographic methods but differ by operating pressures (HPLC < 6000 psi < UHPLC ). Components of HPLC and UHPLC systems include columns, detectors, pumps, autosamplers and column heaters. Explore a range of UHPLC and HPLC columns for your specific sample needs including reverse phase, normal phase, ion exchange, HILIC, ion exclusion and size exclusion columns. For more specialized HPLC, explore FPLC, countercurrent LC and simulated moving bed systems. Find the best UHPLC and HPLC equipment in our peer reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.AntibodiesAntibodies are used in techniques such as confocal and fluorescence microscopy, flow cytometry, ELISA, ELISPOT, immunohistochemistry, western blotting and immunopreciptation. Select specific antigen reactivity, high specific affinity, low non-specific binding, monoclonal or polyclonal, primary or secondary antibodies and associated conjugates such as an enzyme or dye for visualization.Monoclonal AntibodiesMonoclonal antibodies (mAbs) are lab-made molecules that can bind to specific antigens on cells, making them highly effective in treating cancers, autoimmune diseases, and infections. These targeted therapies are transforming the treatment landscape for many conditions. Browse our peer-reviewed product directory to find monoclonal antibodies for research and clinical applications; compare products, check reviews, and get pricing directly from manufacturers.

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New Monoclonal Antibody HPLC Columns from Thermo Fisher Scientific