New Modular Detection Platform is User-Configurable

Beckman Coulter, Inc. will introduce the PARADIGM™ Detection Platform, a unique, modular system that allows quick and easy configuration by the user, at LabAutomation2007.

The platform features a selection of cartridges that can be interchanged in less than five minutes to meet different assay needs, making this the first user-upgradable and -configurable multimode reader. It is ideal for labs with multiple users and applications. The high-throughput detector reads on the fly, in formats from 6 to 1,536 wells.

Eight different cartridges will be available, based on detection modes including fluorescence polarization, time-resolved fluorescence, dual-label fluorescence (including FRET) and luminescence. A monochromator-based absorbance cartridge will also be offered. Future cartridges, including models specifically designed for the new BioRAPTR FRD™ microfluidic workstation, are in development. Beckman Coulter will also provide custom-labeled cartridges for these read modes, to meet unique user needs. The cartridges contain application-specific elements, including wavelength-tuned light sources and optics, that can be interchanged on the detector.

The PARADIGM system software comes with a portfolio of generic protocol templates for the most common detection measurements to streamline user start-up and operation. Assay protocols for third-party chemistry kits are also included, allowing the user to simply enter the number of samples and read the plate. The menu of kit-specific assay protocols will be expanded through ongoing development with several reagent partners. An Auto Update software feature will allow the user to preview available assay protocols and install them with a single click. The PARADIGM Detection Platform operates as a standalone instrument or it can be integrated with Beckman Coulter Biomek^® liquid handlers and new BioRAPTR low-volume workstation. It is ideal for a wide range of standard and cell-based assays such as GPCR, green fluorescent protein, apoptosis, cytotoxicity, nuclear receptors and kinases.

“Detection modes are difficult and costly to add to other multimode detectors once the systems are installed. This can result in compromised performance and lab downtime,” commented Jim Barry, marketing manager for Beckman Coulter. “Our new cartridge system truly redefines modularity, enabling the user to maximize return on the platform investment.”

Beckman Coulter expects to begin shipping the PARADIGM Detection Platform at the end of the first quarter of this year.