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New Content Screening Platform Advances High-Content Analysis for Cancer Applications

7 Apr 2014
Sarah Thomas
Associate Editor

Product news

A new high-content screening software platform enables cancer researchers to uncover more about basic and advanced cellular function to accelerate cell-based research. The Thermo Scientific HCS Studio 2.0 is a high-content quantitative imaging and analysis software platform for a range of cancer research applications, including angiogenesis and migration/invasion, as well as the development of three-dimensional models of cancer stem cells and spheroid tumors.

The new Thermo Scientific HCS Studio 2.0, coupled with Thermo Scientific high content analysis platforms, are increasingly being used in cancer biology as they are well suited for large-scale, high-throughput biology, including complex morphological analyses of cells, cell structure, and aggregations of cells in colonies, yet simple enough to be applied to everyday assays such as viability and proliferation.

The Thermo Scientific HCS Studio 2.0 and the ArrayScan XTI High Content Analysis (HCA) platform will be demonstrated during the American Association for Cancer Research (AACR) 105th Annual Meeting (Booth #1107), April 5 - 9, 2014 at the San Diego Convention Center.

“The challenges posed by complex cancer applications and cell models demand new types of quantitative analysis techniques, and our new software continues to enable researchers with innovative assay techniques and functionality, allowing further discovery using complex cell models,” said Scott Keefer, manager of product marketing, cellular imaging and analysis, Thermo Fisher Scientific. “With our new HCS Studio 2.0 software, coupled with the Thermo Scientific ArrayScan XTI HCA Infinity Configuration enabled for 3D confocal imaging, our customers can address more assay and cell types than ever before while managing the complexities of high-content technology with user-guided, task-oriented software.”


Featuring a validated image processing tool and a powerful yet simple user interface, the HCS Studio 2.0 provides researchers with innovative assay techniques and functionality, allowing further discovery using complex cell models.

Additional features include:
• Directed Assay or Full Development Environment: Pick from validated assays or a customized design with a full suite of image processing tools
• Simple interactive tools for assay optimization: Best-in-class user tools to improve the performance and accuracy of image analysis on cells
• Seamless Integration: Works with software from Thermo Scientific High-Content Imaging platforms for a scalable quantitative cell analysis platform

Tags

Cell / Tissue CultureCell culture or tissue culture is used to study the biology of cells or tissues and to isolate cellular products in an environment which can be manipulated and well defined. Accurately control your culture environment with bioreactors or culture incubators, bind your cells to a surface or together with an extracellular matrix. Distinguish cell types with differential media or proliferate cells with certain characteristics using selective media. Enrich your media with supplements such as growth factors, sera and vitamins. Find the best cell and tissue culture products, kits and equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Data AnalysisData analysis hardware and software is available to make data processing straight-forward yet powerful. Data software can be used for math and stats, technical graphing and image analysis. In addition, software is available for specific data analysis of electrophoresis, densitometry, ELISA and DNA sequencing.Gel Doc / Image AnalysisGel documentation (gel doc) or gel imaging systems are used for the analysis of proteins, antibodies and nucleic acid immobilized in polyacrylamide or agarose gels, membranes or microarrays. Explore a range of a gel imaging systems, densitometers, scanners, transilluminators or UV lamp + CCD cameras for your image analysis solutions. Colorimetric, fluorescent and/or radioisotopic samples can be visualized and documented for further analysis. See gel doc / Image analysis software for quantitative 1D and 2D analysis of your samples. Find the best gel doc / image analysis products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Cell-Based AssaysCell-based assays are used to monitor the presence, quantity and activities of a desired cellular analyte including drug molecules or biomarkers. This can reveal information on cell health (apoptosis, cytotoxicity, viability and proliferation assays), cell metabolism, cell migration and cell signaling mechanisms. Find the best cell-based assay products, kits and equipment with our peer reviewed product directory: compare products, check customer reviews and receiving pricing direct from manufacturers.High-Content ScreeningHigh-content screening (HCS), also known as high-content analysis (HCA), is a high-throughput technique used in drug discovery to identify substances that alter the phenotype of cells. HCS uses fluorescent microscopic imaging and automated image analysis to investigate cellular events such as apoptosis, cell viability, GPCR activation, oxide production, neurite outgrowth, and cell signaling. Find the best fluorescent labeling reagents, cellular assays, and high-content imaging systems in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.TumorsTumor research focuses on understanding abnormal cell growth that leads to cancer. Identifying biomarkers, studying tumor microenvironments, and developing targeted therapies are critical for advancing cancer treatment. Early detection and personalized treatment options are key to improving outcomes for patients. Browse our peer-reviewed product directory to explore tools for tumor research, diagnostics, and cancer therapies; compare products, read customer reviews, and get pricing directly from manufacturers.Quantitative AnalysesQuantitative analyses involve measuring the amount or concentration of a substance in a sample using analytical techniques. These analyses are essential in fields like chemistry, biology, and environmental science. Explore quantitative analysis tools in our peer-reviewed product directory; compare products, check reviews, and get pricing directly from manufacturers.Cancer ResearchAlthough cancer is often referred to as a single condition, it actually consists of more than 100 different diseases. Microscopy, mass spectrometry, high throughput sequencing and flow cytometry are some of the most common techniques employed in cancer research labs.Image AnalysisImage analysis involves the extraction of meaningful information from images, often using software to quantify and interpret visual data. It is widely used in cell biology, material science, and diagnostics. Increasingly, AI is being used to streamline image analysis. Explore image analysis tools in our peer-reviewed product directory; compare products, check reviews, and get pricing directly from manufacturers.AACRThe American Association for Cancer Research (AACR) is a leading organization focused on cancer research and treatment. It provides a platform for scientists, healthcare professionals, and industry leaders to share knowledge and collaborate in the fight against cancer.

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New Content Screening Platform Advances High-Content Analysis for Cancer Applications