New CellReporter live cell based assay system from Genetix

17 Apr 2007

Product news

Genetix Ltd (New Milton, UK) has announced the introduction of a new cell based assay platform, CellReporter. Complementing the company’s existing technologies for cell identification and selection, the new CellReporter is a powerful platform for fast, highly productive quantitative screening that produces qualified data for multiwell, live cell assays at very high speed, using white light and multiplexed fluorescence.

In an industry first, Genetix has combined the speed of a plate reader, the quality of a microscope and the insight of high content assays. CellReporter assesses multiple parameters in parallel, delivering immediate analysis and normalization of data. Easy to interpret features that validate assay read outs are built-in, ensuring that a compound hit list is available minutes following assay completion. This compares to several days for traditional workflows. Only biologically relevant data feeds into subsequent data processing packages.

CellReporter includes campaign driven software, imaging instrumentation and assay reagents for essential applications such as cell viability and morphology, cell proliferation, and apoptosis.

Data from Cell Reporter is stored in a standard format to allow export to other processing packages if required. In addition, by integrating with data from Genetix’s CloneSelect Imager, scientists have a useful direct link between information about cell growth and assay data from CellReporter.

For more details of CellReporter and the entire cell biology portfolio of products from Genetix, contact your local organization, or visit the article webpage.

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Microplate Readers / DetectorsMicroplate readers are used to automate the detection and analysis of labeled or label-free components in microplates during assays or live-cell monitoring. Microplate readers are generally distinguished by their mode of detection. Types include absorbance, luminescence, fluorescence intensity, fluorescence polarization, TRF / FRET and multimode microplate readers. Microplate readers deliver a high throughput of samples by reading multiple wells simultaneously, with the 96-well format the most commonly used. As a result, microplate readers are often used in the drug discovery, bioassays, research and pharmaceutical industries for screening applications. Microplate loading can also be automated, with robotic microplate stackers to increase throughput. Find the best microplate readers in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Cell-Based AssaysCell-based assays are used to monitor the presence, quantity and activities of a desired cellular analyte including drug molecules or biomarkers. This can reveal information on cell health (apoptosis, cytotoxicity, viability and proliferation assays), cell metabolism, cell migration and cell signaling mechanisms. Find the best cell-based assay products, kits and equipment with our peer reviewed product directory: compare products, check customer reviews and receiving pricing direct from manufacturers.High-Content ScreeningHigh-content screening (HCS), also known as high-content analysis (HCA), is a high-throughput technique used in drug discovery to identify substances that alter the phenotype of cells. HCS uses fluorescent microscopic imaging and automated image analysis to investigate cellular events such as apoptosis, cell viability, GPCR activation, oxide production, neurite outgrowth, and cell signaling. Find the best fluorescent labeling reagents, cellular assays, and high-content imaging systems in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.