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New Cancer Research Tool: Roche's CIM-Plate 16

18 Nov 2009
Sarah Sarah
Marketing / Sales

Product news

Roche Applied Science announces the availability of the new CIM-Plate 16 for their xCELLigence System for cell analysis, for use in cancer research. The 16-well culture plate features electronic sensors for the direct study of cell migration and invasion on the xCELLigence RTCA DP Instrument.

The system delivers unbiased data without disturbing cells due to labeling and allows researchers to monitor cell invasion and migration continuously in real-time throughout the entire duration of the experiment. The user can combine E-Plate 16 to measure cell proliferation and CIM-Plate 16 to quantify cell migration and invasion, thus making full use of the flexibility that the RTCA DP Instrument has to offer.

The xCELLigence System allows scientists to monitor cellular events in real time without having to incorporate labels. The system measures electrical impedance across interdigitated micro-electrodes integrated on the bottom of tissue culture E-Plates. The impedance measurement provides quantitative information about the biological status of the cells, including cell number, viability, and morphology.

The CIM-Plate 16 is a single-use, disposable device for performing cell invasion and cell migration assays on the RTCA DP Instrument. The CIM-Plate 16 is comprised of a plate cover (lid), an upper chamber and a lower chamber. The upper chamber has 16 wells that are sealed at the bottom with a microporous polyethylene terephthalate (PET) membrane; microfabricated gold electrode arrays are located on the bottom side of the membrane. The median pore size of this membrane is 8 µm. The lower chamber has 16 wells, each of which serves as a reservoir for media and any chemoattractant for the cells in corresponding upper chamber wells. The CIM-Plate 16 Assembly Tool can be used to assemble the lower and upper chambers once the media has been added.

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MicroplatesMicroplates are multi-well plates used to increase the throughput of biological investigations. The number of wells microplates contain can range from 6 to 3243 wells, with the 96-well format being the most commonly used. Microplates can come tailored for a range of applications including cell culture, PCR, filtration, storage, non-binding surface, protein crystallization, as well as pre-coated, deep well and normal Standard microplates. Additionally, options for microplate colors include clear , black, white or black with clear bottom and white with clear bottom for absorbance microplate reader applications. Find the best microplates for your lab in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Cell Lines Stem Cells and Primary CellsPrimary cell cultures, established cell lines and stem cells are vital for <i>in vitro</i> and <i>ex vivo</i> experimentation. High-quality cells, optimized for your applications, alongside optimized cell substrates, growth medium and supplements, are critical for experimental success. Explore a range of cells suitable for your applications, including isogenic cell lines, competent cells, induced pluripotent stem cell (iPSC)-derived cell lines, fungal/bacterial/mammalian cell lines, stem cells and cancer cell lines. Find the best cells for your research in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.High-Content ScreeningHigh-content screening (HCS), also known as high-content analysis (HCA), is a high-throughput technique used in drug discovery to identify substances that alter the phenotype of cells. HCS uses fluorescent microscopic imaging and automated image analysis to investigate cellular events such as apoptosis, cell viability, GPCR activation, oxide production, neurite outgrowth, and cell signaling. Find the best fluorescent labeling reagents, cellular assays, and high-content imaging systems in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.

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New Cancer Research Tool: Roche's CIM-Plate 16