New Bio-Rad Literature Describes Proteon XPR36 Protein Interaction Array System Sensor Chips

23 Aug 2007

Product news

Bio-Rad Laboratories, Inc., a multinational manufacturer and distributor of life science research products and clinical diagnostics, today announced the availability of a product information sheet (Bulletin 5404) that describes Bio‑Rad’s ProteOn™ XPR36 protein interaction array system sensor chips. Used with the ProteOn XPR36 system, the three sensor chips combine advanced surface chemistries with an alternate approach to surface chemistry activation to optimize ligand binding activity.

The product information sheet offers features and benefits of each of the chips and explains how they can conduct up to 36 unique biomolecular assay interactions simultaneously in one experiment. In addition, the literature describes the chips’ ability to provide reliable and real-time measurement of multiple protein-protein, protein-peptide, protein-small molecule, and protein-DNA interactions. Extensive supporting data of the chips’ capabilities in the form of tables and graphics are also provided in the literature.

The three ProteOn system chips include:

  • The ProteOn GLC sensor chip is designed for protein-protein interaction analysis;
  • the ProteOn GLM sensor chip for protein-small molecule applications; and
  • the ProteOn NLC sensor chip for immobilization of biotinylated proteins, peptides, and nucleic acids. Chip ordering information is also provided.

The ProteOn instrument and chip system is specifically designed for scientists conducting antibody research and development, protein interface analysis, interaction proteomics, and drug target interactions. The system and chips may also be used by pharmaceutical service providers.

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BiosensorsBiosensors are devices used to detect an analyte using biological molecules specific to the analyte coupled to a detector. Biosensor instruments may be photometric, typically using surface plasma resonance (SPR), electrochemical or QCM (quartz crystal microbalance) biosensors. Biosensors should be selective, portable, robust and sensitive and have a fast response time. Systems may be manual or automated and usually have associated software.Lab-on-a-ChipLab-on-a-chip (LOC) technology uses microfluidic chips, such as microarrays, to perform biochemical assays on a small scale. Benefits of lab-on-a-chip include the small volume of sample required as well as the speed of analysis. In selecting lab-on-a-chip devices consider the assay, cost, reliability, sensitivity and signal to noise ratio.ProteomicsProteomics is the systemic bioinformatics study of proteins and amino acids, including their structure, size, function and identification. Tools used in proteomics include chromatography, blotting and gels, protein arrays, mass spectrometry and ELISA and associated analysis software. Analyzers and proteomic systems should be sensitive, high resolution, fast and may be automated for high-throughput.Microarray AnalysisMicroarrays, also known as biochips, are used for the detection and analysis of multiple genes, proteins, antibodies, or biomarkers on a single microchip. This can reveal information on protein or gene expression, single nucleotide polymorphism (SNP), copy number variation (CNV), epigenetics and patient health in clinical diagnostic tests. Discover a range of microarray scanners and prefabricated antibody, protein, RNA and DNA microarrays for your analysis or consider creating your own custom microarrays with a microarray printer. Find the best microarray products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Cell-Based AssaysCell-based assays are used to monitor the presence, quantity and activities of a desired cellular analyte including drug molecules or biomarkers. This can reveal information on cell health (apoptosis, cytotoxicity, viability and proliferation assays), cell metabolism, cell migration and cell signaling mechanisms. Find the best cell-based assay products, kits and equipment with our peer reviewed product directory: compare products, check customer reviews and receiving pricing direct from manufacturers.