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New Alliance Brings Enhanced Sample Preparation for Drug Development Scientists

Waters

Firms to co-market new semi-automated sample preparation approach for protein therapeutics glycosylation profiling

11 Jun 2017
Weylan Kiam-Laine
Microbiologist

Product news

Waters Corporation and Andrew Alliance have signed an agreement that will bring drug development scientists an easy-to-use, semi-automated sample preparation approach for released N-glycan profiling and analysis by LC and LC-MS. Under the co-marketing agreement, Waters will combine its existing Glycoworks® RapiFluor-MS® N-Glycan Kit with an Andrew pipetting robot that will allow laboratories to meet the demands on them for glycan profiling while improving the accuracy and precision of LC and LC-MS results.

“With the increasing number of protein therapeutics in development, the demand for glycan analyses is growing exponentially,” said Dr. Jeff Mazzeo, Vice President, Consumables Group, Waters Corporation. “The combination of the Andrew robot with the Waters RapiFluor-MS N-Glycan Kit is an ideal solution for automating large numbers of routine, high-quality released N-glycan analyses.”

Piero Zucchelli, CEO and Founder of Andrew Alliance stated, “The Waters Glycoworks RapiFluor-MS N-Glycan Kit offers strategic and critical value that should not be compromised by the uncertainty induced by manual sample pipetting. The use of the Andrew robot for unattended execution of the kit’s sample preparation workflow addresses this point and enables scientists to make decisions based on solid and reproducible data.”

Most biotherapeutic proteins available on the market today are glycoproteins. The heterogeneous sugar molecules, or glycans, on these proteins affect the potency, stability, and therapeutic safety profiles of these drugs. As a result, biopharmaceutical companies must provide detailed structural information on these glycans when submitting new applications to regulatory authorities and must monitor them throughout the manufacturing process.

Since the launch of the GlycoWorks RapiFluor-MS N-Glycan Kit in February of 2015, laboratories worldwide have seen the benefits of simplified sample preparation and achieved unprecedented levels of sensitivity and speed.

The combination of Waters® and Andrew Alliance technologies takes released Nglycan sample preparation to the next level by making it simpler and more efficient to scale up samples tested with the same enhanced optical and MS sensitivity users have experienced with the RapiFluor-MS labelling reagent. Semi-automation of released N-glycans is now affordable and easily accessible.

For more information about the GlycoWorks RapiFluor-MS N-Glycan Kit, visit www.waters.com/glycans.

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LC-MSLC-MS (liquid chromatography-mass spectrometry) systems and equipment are used for separation and quantitative analysis of complex mixtures, combining liquid chromatography and mass spectrometry. Quantify proteins, contaminants, pesticides or screen for drug metabolites with a high level of sensitivity. LC-MS systems and equipment include reverse phase, normal phase and specialized columns integrated with various MS detectors such as time-of-flight (TOF), quadrupole, orbitrap or ion trap mass analyzers. LC-MS/MS instruments equipped with a qTOF or triple quadrupole analyzer give greater sensitivity and resolving power to your analysis. Find the best LC-MS equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.ProteomicsProteomics is the systemic bioinformatics study of proteins and amino acids, including their structure, size, function and identification. Tools used in proteomics include chromatography, blotting and gels, protein arrays, mass spectrometry and ELISA and associated analysis software. Analyzers and proteomic systems should be sensitive, high resolution, fast and may be automated for high-throughput.Protein PurificationProtein purification is a vital step in drug discovery, therapeutics, biotech and life science research. The purification process typically involves subcellular or membrane protein extraction with cell lysis kits, separation of proteins from cell debris by filtration or spin columns, and the isolation of proteins of interest from other proteins and impurities with affinity purification (including fusion protein tags and antibody binding proteins A, G and L), immunoprecipitation or chromatographic methods, such as ion exchange, size exclusion and immobilized metal affinity chromatography. All purification methods come in multiple formats for your laboratory needs, including agarose or magnetic beads, resins, columns and filter plates. Find the best protein purification equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Robotic InstrumentsRobotic instruments can be used for high-throughput automation of many lab processes. Such processes use instruments for assays like cell based assays and ELISA, for sample preparation like shakers, centrifuges and incubators, and for analysis such as sequencing and western blot analyzers. Useful features of robotic instruments include speed, reproducibility, barcode readers, software and automation.Automated Liquid HandlingAutomated liquid handling equipment is used to mix, dilute and dispense allotted volumes of liquid into microplates and other vessels automatically. The robotic, liquid handling arms can dispense from single channel to 3456 multichannel as well as operate nanoliter dispensing, enabling high throughput of samples. Find the best automated liquid handlers in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Sample PreparationSample preparation can improve the quality and speed of separation techniques. Products to assist sample preparation include filtration equipment, evaporators, membranes and sieves.AutomationAutomation in laboratories and manufacturing processes enhances efficiency, precision, and scalability by reducing the need for manual intervention. It plays a critical role in improving productivity, minimizing human error, and accelerating workflows in fields like diagnostics, drug development, and industrial testing. Automation technologies include robotic systems, automated liquid handlers, and process control systems that streamline complex tasks and ensure consistent, reproducible results. Explore our peer-reviewed product directory to discover the best automation solutions, compare options, read user reviews, and get prices directly from manufacturers.Drug DevelopmentDrug development refers to the process of bringing a new drug to market.Protein BiologyThe analysis of protein expression, identity and function is vital for many areas of life science research and drug discovery. Some of the most commonly used techniques in protein analysis include Western blotting, electrophoresis and mass spectrometry.

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