NanoTemper Technologies arms gene therapy scientists with static light scattering for development of AAVs

They hope to sharpen the toolkit of gene therapy scientists with the introduction of SLS

25 Mar 2022
Rory Shadbolt
Publishing / Media

Product news

NanoTemper Technologies today announced the addition of Static Light Scattering (SLS) to their wildly successful Prometheus Panta, turning their instrument best known for being the new gold standard in protein stability characterization for biologics into a tool that will uplevel the tool kit for any AAV-focused gene therapy scientist.

“We’ve been keeping an eye on the needs of gene therapy researchers for years,” stated CEO Philipp Baaske. “There’s a limited amount of AAV sample available, and they’re faced with having to take what feels like an impossible number of measurements to ensure they select the best vectors. And it was important to us to address this.”

Prometheus Panta with SLS allows scientists to characterize their AAV vectors – whether it be serotyping, formulation, or capsid filling and leaking – with very little sample. “We already have a number of customers who have found success with Prometheus Panta in the gene therapy field,“ points out Charles Heffern, Product Manager. “They love the reliability of the instrument, easy operation by any technician, and the high-quality results that have been proven time and time again.”

Want the latest science news straight to your inbox? Become a SelectScience member for free today>>

Prometheus Panta for biologics stability profiling with particle sizing and molecular weight determination by NanoTemper Technologies

NanoTemper Technologies

Prometheus Panta monitors the thermal stability, turbidity, and dispersity of a protein sample, and provides the highest-resolution, highest-quality data for ranking and selecting candidates. Prometheus Panta outputs critical quality parameters about your therapeutic proteins of interest, including: their hydrodynamic radius, molecular weight, self-association propensity, and deltaG of unfolding.

(2)

Links

Tags

Combinatorial ChemistryCombinatorial chemistry, also known as combichem, is a technique used in drug discovery to create libraries of structurally related compounds. A library is generated by synthesis with a chemical reactor system or by computer-based modeling of compound combinations. When undertaking combinatorial chemistry consider reagents, buffers, resins and standards.Drug DiscoveryDrug discovery is the process of identifying potential new medications, involving stages such as target identification, compound screening, and preclinical development. It relies on cutting-edge technologies like high-throughput screening, artificial intelligence, and molecular modeling to accelerate the identification of drug candidates. Drug discovery plays a pivotal role in developing new therapies for diseases ranging from cancer to rare genetic disorders. Browse our peer-reviewed product directory to find the latest drug discovery technologies, compare options, check customer feedback, and get pricing directly from manufacturers.Drug DevelopmentDrug development refers to the process of bringing a new drug to market.Drug Discovery & Development Screening