Multi-skilled microplate reader finds many applications

3 Jan 2008

Product news

The Plate Chameleon V microplate reader incorporates six different detection technologies and uses fibreless detection geometry to guarantee the highest performance from all of them.

No surprise then that it is finding a growing range of applications. Cell signalling and viability, enzyme kinetics, toxicity and drug screening, study of protein structures and functions, immunoassays, protein and nucleic acid quantification, gene expression, the detection of ATP and reactive oxygen species are among the many on the list.

But this versatility is not for everyone; many users need only one or two of the functions initially. That's why LabLogic Systems is offering the reader on a modular basis, with the option to add others as the need arises.

Users can start with, for example, a microplate luminometer and invest in fluorescence and absorbance technologies later when their research progresses.

The full version adds radiometric and non-radiometric detection and liquid scintillation counting. Temperature controlled incubation, full 21 CFR part 11 compliant software and onboard injectors are also available.

The Plate Chameleon has a footprint only slightly bigger than a laptop, so it fits in everywhere and is easy to transport. You can run it from its own keypad or a PC, and download the results to the sophisticated Hidex MikroWin Data Analysis Software, MS Excel or other data reduction programs.

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ProteomicsProteomics is the systemic bioinformatics study of proteins and amino acids, including their structure, size, function and identification. Tools used in proteomics include chromatography, blotting and gels, protein arrays, mass spectrometry and ELISA and associated analysis software. Analyzers and proteomic systems should be sensitive, high resolution, fast and may be automated for high-throughput.High-Throughput ScreeningHigh-throughput screening (HTS) is an automated drug discovery technique for identification of active compounds against a compound library. Use HTS readers and integrated assay preparation / analysis workstations to screen your compounds. Identify active compounds against various HTS libraries, including membranes, proteins and peptides and HTS cell lines. Find the best high-throughput screening products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Data AnalysisData analysis hardware and software is available to make data processing straight-forward yet powerful. Data software can be used for math and stats, technical graphing and image analysis. In addition, software is available for specific data analysis of electrophoresis, densitometry, ELISA and DNA sequencing.Microplate Readers / DetectorsMicroplate readers are used to automate the detection and analysis of labeled or label-free components in microplates during assays or live-cell monitoring. Microplate readers are generally distinguished by their mode of detection. Types include absorbance, luminescence, fluorescence intensity, fluorescence polarization, TRF / FRET and multimode microplate readers. Microplate readers deliver a high throughput of samples by reading multiple wells simultaneously, with the 96-well format the most commonly used. As a result, microplate readers are often used in the drug discovery, bioassays, research and pharmaceutical industries for screening applications. Microplate loading can also be automated, with robotic microplate stackers to increase throughput. Find the best microplate readers in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.ADME-ToxicologyADME-toxicology (ADME-Tox) studies are used in pharmacology and pharmacokinetics to assess the activity/toxicity of drugs <i>in vivo</i> or <i>in vitro</i>. Find bioassays for absorption, distribution, metabolism, and excretion of drug molecules including cytotoxicity, transporter/permeability, metabolism and activity assays as well as hepatocytes and cell lines for ADME. Find the best ADME-toxicology products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Cell-Based AssaysCell-based assays are used to monitor the presence, quantity and activities of a desired cellular analyte including drug molecules or biomarkers. This can reveal information on cell health (apoptosis, cytotoxicity, viability and proliferation assays), cell metabolism, cell migration and cell signaling mechanisms. Find the best cell-based assay products, kits and equipment with our peer reviewed product directory: compare products, check customer reviews and receiving pricing direct from manufacturers.ScintillationScintillation is an analytical technique used to measure the ionizing radiation of an analyte. At the core of a scintillation counter is a sensor and detector, where the sensor is typically a scintillator crystal. Scintillation also includes liquid scintillation, radiometers and particle counters. Key features of scintillator counters include high resolution, automated multi-detection and high counting efficiency.