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MSIA Microcolumns from Thermo Fisher Scientific for Tecan’s Freedom EVO Platform

Thermo Fisher Scientific
16 Feb 2016
Lois Manton-O'Byrne, PhD
Executive Editor

Product news

The newest addition to the MSIA product family, the MSIA Streptavidin-EVO from Thermo Fisher Scientific is designed to bring the novel affinity capture technology of MSIA microcolumns to the Tecan Freedon EVO® series of platforms, fitted with 96 multichannel liquid handling arm (MCA 96). Offering features to overcome the challenges associated with conventional methods of affinity purification, MSIA Streptavidin-EVO allows researchers to:

  • Reduce background noise and carryover
  • Meet productivity demands while reducing assay development timelines
  • Obtain reliable and consistent results
  • As an automated system, it supports easy transfer of assays between labs and eliminates user induced errors.

By combining innovative affinity purification MSIA microcolumn technology, with proven high-throughput automation solutions from Tecan, MSIA Streptavidin-EVO microcolumns are designed to transform the way you perform your large molecule bioanalysis.

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MSIA™ Microcolumns for the Freedom EVO Platform

Thermo Fisher Scientific

Next generation large molecule bioanalysis made easier by combining the Thermo Scientific™ innovative MSIA™ technology with Tecan advanced, robust and easy-to-use liquid handling. MSIA affinity microcolumns, designed for Freedom EVO platform (MCA 96 head), provide innovative enablement in the areas ranging from bioanalysis of therapeutic mAbs, antibody-drug conjugates (ADC), biotransformation [in-vivo modifications, drug-antibody ratio (DAR)], preclinical and clinical drug trials (PKPD, DMPK, and ADME) to biomarker and proteins analysis. This unique solution is designed to deliver the accuracy, reliability and automation you need to be successful.   Features: Robust Automation:  Simply program the Freedom EVO to elute the analyte from complex biological samples and let the automated platform carry the load. Highly sensitive: Analyze proteins of interest down to femtomole level. Enhanced characteristics:  Detects multiple protein variants for qualitative and quantitative bioanalysis in a single assay. Contaminant-free: proprietary molecular trapping microcolumn technology prevents matrix injection that would impact LC-MS function. High signal-to-noise ratio: Innovative sample interface technology reduces matrix loss, reagent carryover and non-specific binding. Time Savings: Microfluidic channels drive kinetic interactions significantly decreasing incubation time required to process the samples, while the MCA 96 head enables parallel processing of 96 samples. Reproducible: Consistent performance for assay reproducibility. Preserving samples: Small sample volumes (as low as 10μL) and a reduced requirement for repeating experiments. MSIA Streptavidin EVO microcolumns provide end user flexibility to analyze their specific targets of interest.

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UHPLC and HPLCHigh performance liquid chromatography (HPLC) and ultra high performance liquid chromatography (UHPLC), also known as UPLC, are analytical techniques used to separate, identify and quantitate components of complex mixtures including biological samples such as proteins and lipids as well as chemical mixtures of pesticides, drugs and oils. Both techniques are liquid chromatographic methods but differ by operating pressures (HPLC < 6000 psi < UHPLC ). Components of HPLC and UHPLC systems include columns, detectors, pumps, autosamplers and column heaters. Explore a range of UHPLC and HPLC columns for your specific sample needs including reverse phase, normal phase, ion exchange, HILIC, ion exclusion and size exclusion columns. For more specialized HPLC, explore FPLC, countercurrent LC and simulated moving bed systems. Find the best UHPLC and HPLC equipment in our peer reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Protein PurificationProtein purification is a vital step in drug discovery, therapeutics, biotech and life science research. The purification process typically involves subcellular or membrane protein extraction with cell lysis kits, separation of proteins from cell debris by filtration or spin columns, and the isolation of proteins of interest from other proteins and impurities with affinity purification (including fusion protein tags and antibody binding proteins A, G and L), immunoprecipitation or chromatographic methods, such as ion exchange, size exclusion and immobilized metal affinity chromatography. All purification methods come in multiple formats for your laboratory needs, including agarose or magnetic beads, resins, columns and filter plates. Find the best protein purification equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Automated Liquid HandlingAutomated liquid handling equipment is used to mix, dilute and dispense allotted volumes of liquid into microplates and other vessels automatically. The robotic, liquid handling arms can dispense from single channel to 3456 multichannel as well as operate nanoliter dispensing, enabling high throughput of samples. Find the best automated liquid handlers in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.PurificationPurification techniques are essential for isolating compounds of interest from complex mixtures, such as proteins, nucleic acids, and chemicals. These techniques are critical in biochemistry, drug development, and environmental studies. Explore purification systems in our peer-reviewed product directory; compare products, check reviews, and get pricing directly from manufacturers.Liquid Handling WorkstationLiquid handling workstations automate the process of sample preparation, improving accuracy and efficiency. These systems are essential for high-throughput applications in biological, chemical, and pharmaceutical research, reducing human error and increasing reproducibility. Workstations come equipped with robotic arms, pipetting tools, and other accessories to streamline lab workflows. Explore liquid handling workstations in our peer-reviewed product directory; compare products, check reviews, and get pricing directly from manufacturers.BiopharmaceuticalsBiopharmaceuticals are proteins and other compounds (such as nucleic acids) produced by living organisms that have uses as therapeutics or for in vivo diagnostics. The most well known example of a biopharmaceutical product, and the first to be approved for therapeutic use, was recombinant human insulin.

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MSIA Microcolumns from Thermo Fisher Scientific for Tecan’s Freedom EVO Platform