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Molecular Devices Launches ImageXpress Micro XLS System for Wide-field High Content Screening

Molecular Devices®
23 Sept 2013
Kerry Parker
CEO

Product news

Single integrated system offers enhanced performance for greater speed and flexibility in fixed-end point and time-lapse live-cell studies.

Molecular Devices® has announced the launch of the ImageXpress® Micro XLS System, the latest improvement to its high content screening portfolio. Developed as a single wide-field integrated system with unlimited hardware and software configurations, system-wide improvements offer enhanced speed and flexibility to both fixed-end point and time-lapse live-cell studies.

Drawing on previous success with the ImageXpress Micro XL System, the latest development combines leading edge hardware components with the next generation MetaXpress® Software in one package, to deliver greater throughput and performance. With a screening capability of > 50,000 wells per day, the system allows for faster characterization of highly heterogeneous samples from large, diverse populations, and identification of rare sub-populations.

The open modular design of the ImageXpress Micro XLS System allows for a variety of configurations, affording research labs total flexibility in addressing unique applications. The system includes environmental control, on-board liquid handling, and brightfield capabilities for label-free cellular monitoring over time-lapse experiments, eliminating the need for toxic nuclear stains in live-cell imaging. A variety of light engines is available at time of purchase to support applications such as near infrared (IR) or ratiometric imaging. Custom analysis for specific measurements can be easily created and shared.

“We have seen increasing demands for assays to be run at higher throughput, and to develop biologically relevant assays using new dyes, antibodies or cell models,” noted Grischa Chandy, Senior Product Manager of Molecular Devices, Imaging. “The ImageXpress Micro XLS System addresses these demands on both fronts. It brings significant speed improvements to screening labs so plates can turn to hits faster, and provides the flexibility researchers need in designing and validating an assay.”

The ImageXpress Micro XLS System will debut at MipTec 2013.

For more information, please visit: www.moleculardevices.com/hcs

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High-Content ScreeningHigh-content screening (HCS), also known as high-content analysis (HCA), is a high-throughput technique used in drug discovery to identify substances that alter the phenotype of cells. HCS uses fluorescent microscopic imaging and automated image analysis to investigate cellular events such as apoptosis, cell viability, GPCR activation, oxide production, neurite outgrowth, and cell signaling. Find the best fluorescent labeling reagents, cellular assays, and high-content imaging systems in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Automated Liquid HandlingAutomated liquid handling equipment is used to mix, dilute and dispense allotted volumes of liquid into microplates and other vessels automatically. The robotic, liquid handling arms can dispense from single channel to 3456 multichannel as well as operate nanoliter dispensing, enabling high throughput of samples. Find the best automated liquid handlers in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Light MicroscopyLight microscopes or optical microscopes are used to visualize microscale objects under magnification, including cells, clinical specimens and materials. Lab equipment for light microscopy includes confocal microscopes, fluorescence microscopes, zoom and stereo microscopes. Microscope slides and imaging reagents are available for visualizing samples, as well as various microscope stages and incubators for large or temperature-sensitive samples. Find the best light microscopes in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Cell ImagingCell imaging can be achieved using a number of techniques including confocal microscopy, transmission electron microscopy, atomic force microscopy, and light sheet microscopy.Liquid Handling WorkstationLiquid handling workstations automate the process of sample preparation, improving accuracy and efficiency. These systems are essential for high-throughput applications in biological, chemical, and pharmaceutical research, reducing human error and increasing reproducibility. Workstations come equipped with robotic arms, pipetting tools, and other accessories to streamline lab workflows. Explore liquid handling workstations in our peer-reviewed product directory; compare products, check reviews, and get pricing directly from manufacturers.ScreeningUsing robotics, data processing and control software, liquid handling devices and sensitive detectors, screening allows a researcher to quickly conduct millions of chemical, genetic or pharmacological tests.

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Molecular Devices Launches ImageXpress Micro XLS System for Wide-field High Content Screening