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MININEPHplus™ with Freelite™ and an Expanded Range of Specialist Protein Assays

27 Jul 2011
bridget bridget
Laboratory Director

Product news

The MININEPHplus™ is a small, stylish semi-automated nephelometer and together with Freelite™ serum free light chain assays (recommended by International Myeloma Working Group guidelines) can be used in diagnosis, prognosis and when monitoring patients with monoclonal gammopathies. The exclusive combination of Freelite and MININEPHplus™ enables laboratories with small Freelite workloads to provide results for this essential assay quickly and easily.

In addition, there is a comprehensive range of specialist protein assays:- IgG, IgA, IgM, IgG1 –IgG4, Rheumatoid Factor, C Reactive Protein, C3, C4, Albumin, Apolipoprotein A1 and B, α-1 Antitrypsin, β2Microglobulin, Anti-Streptolysin O, Caeruloplasmin, Haptoglobin, Microalbumin, Prealbumin, Transferrin, IgG-Low Level (Research Use Only) and C1 Inactivator (Research Use Only).

The MININEPHplus™ is easy to use, with simple on-screen instructions in several languages and assay specific magnetic swipe cards containing pre-programmed calibration curves. Its automatic assay blanking and reagent mixing ensures consistent results and the pre-programmed integrated single button pipette improves precision. An optional hand-held sample barcode scanner plus automatic calculation of sample results gives users confidence in the accuracy of this light and portable analyser.

There is an automatic antigen excess check for Freelite™ assays, a feature often seen only on larger analysers, and small volume free kappa and free lambda kits (30 tests, 2x 15 test vials) allow rapid, cost effective testing for laboratories who are currently sending out samples for Freelite serum free light chain analysis.

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AntibodiesAntibodies are used in techniques such as confocal and fluorescence microscopy, flow cytometry, ELISA, ELISPOT, immunohistochemistry, western blotting and immunopreciptation. Select specific antigen reactivity, high specific affinity, low non-specific binding, monoclonal or polyclonal, primary or secondary antibodies and associated conjugates such as an enzyme or dye for visualization.Assay AssemblyAssay Assembly is technique used in drug discovery to develop assays to test the cytotoxicity, genotoxicity, or other activities of a compound on a cell. Assay assembly requires chip assembly, a delivery system and a detection and analysis method. Beneficial features of assay kits or automated systems include high-throughput, high speed and sensitivity and low signal to noise ratio.ImmunologyImmunological techniques measure and characterize immune responses. Immunology kits and analysis systems often use techniques such as ELISA, radioimmunoassay (RIA) and immunodiffusion assays, Immunohistochemistry, and flow cytometry. Immunologists use equipment such as flow Cytometers, plate readers, plate washers and fluorescent microscopes.Point-of-CarePoint-of-Care Testing (POCT) or Near Patient Testing (NPT) products are available for urine, blood and other clinical chemistry analyses. POCT includes: blood glucose testing, blood gas and electrolytes analysis, rapid coagulation testing (PT / INR), rapid cardiac markers diagnostics, drugs of abuse screening, urine strips testing, pregnancy testing, fecal occult blood analysis, food pathogens screening, hemoglobin diagnostics, infectious disease testing and cholesterol screening.Protein PurificationProtein purification is a vital step in drug discovery, therapeutics, biotech and life science research. The purification process typically involves subcellular or membrane protein extraction with cell lysis kits, separation of proteins from cell debris by filtration or spin columns, and the isolation of proteins of interest from other proteins and impurities with affinity purification (including fusion protein tags and antibody binding proteins A, G and L), immunoprecipitation or chromatographic methods, such as ion exchange, size exclusion and immobilized metal affinity chromatography. All purification methods come in multiple formats for your laboratory needs, including agarose or magnetic beads, resins, columns and filter plates. Find the best protein purification equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.BiomarkersBiomarkers are biological markers which can be measured and evaluated to indicate a biological state. The use of biomarkers in research and diagnosis can indicate a normal or disease state or drug response of cells / tissues. Biomarkers include genetic markers, cell surface markers such as antigens, antibodies or receptors and secreted molecules such as cytokines. An assay system is required for identification of biomarkers. :Clinical TrialsClinical Trials, an essential part of drug discovery process, assess the safety and effectiveness of a new medication or device in the pharmaceutical industry. Clinical Trials are a phased process (Phase 0, Phase I, Phase II, Phase III and Phase IV) which begins after initial preclinical testing.

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