Millipore Unveils Human Cancer Biomarker Panel

2 Oct 2007

Product news

Millipore Corporation, a Life Science leader providing technologies, tools and services for the bioscience research and biopharmaceutical manufacturing industry, today announced the availability of the Beadlyte® Human Cancer Biomarker Panel. The panel includes a Five-plex containing the biomarkers: Macrophage, Migration Inhibitory Factor (MIF), Prolactin, CA-125, Leptin and Osteopontin (OPN); and a Single Plex IGF-II assay. Each of the biomarkers has been identified in various tumor types including lung, breast, prostate and colorectal.

Dr. Gil Mor of Yale University used the Panel in research to detect all Stages of ovarian cancer. The profile of the six biomarkers isolated from serum was used with a unique algorithm developed by Dr. Mor’s laboratory to discriminate accurately between ovarian cancer patients and healthy subjects. The six biomarkers in the Panel demonstrate the significance of assessing biomarkers that change from the body’s response to the presence of cancer cells. Consequently, this panel will be a valuable tool for researchers studying the biochemical mechanisms and signals of all cancer stages.

The assays can be used to quantify these biomarkers in serum, plasma and cell/tissue culture supernatant samples. Each Panel includes all components to run the assay, standards and quality controls for each plex and can be easily adapted for high throughput automation. The Panel is highly sensitive, offering excellent intra- (<11%) and inter-assay (<10%) precision.

The integrated Millipore offers you more innovative technologies and stronger application support to streamline your progress and give you more confidence in your results. We’re deeply committed to having an in-depth understanding of key target classes for selectivity testing, including functional kinase, GPCR, and ion channel profiling assays, as well as extensively validated RIAs, ELISAs, and multiplex assays and bio-analytical service support for research or clinical studies.

MILLIPLEX® MAP Human Cancer Biomarker Panel

Merck

Millipore now proudly offers the MILLIPLEX® MAP Human Cancer Biomarker Panel. The Cancer Biomarker Panel includes both a Five-Plex assay, which simultaneously measures five serum biomarkers, Macrophage Migration Inhibitory Factor (MIF), Prolactin, CA-125, Leptin and Osteopontin (OPN), and a Single Plex IGF-II assay. The combination of the six serum biomarkers that discriminate between disease-free and ovarian cancer patients was characterized and validated by Dr. Gil Mor of Yale University. Using a unique algorithm developed by Dr. Mor's Laboratory, the profile of the six biomarkers in circulation was used to detect all stages (I, II, III and IV) of ovarian cancer with high sensitivity and accuracy. The assays can be used to quantify these biomarkers in serum, plasma, and cell/tissue culture supernatant samples. The kit is for research use only.

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Cell / Tissue CultureCell culture or tissue culture is used to study the biology of cells or tissues and to isolate cellular products in an environment which can be manipulated and well defined. Accurately control your culture environment with bioreactors or culture incubators, bind your cells to a surface or together with an extracellular matrix. Distinguish cell types with differential media or proliferate cells with certain characteristics using selective media. Enrich your media with supplements such as growth factors, sera and vitamins. Find the best cell and tissue culture products, kits and equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.ELISAEnzyme-linked immunosorbent assays (ELISA), also known as enzyme immunoassays (EIA), are used for the detection and quantification of proteins, peptides and antibodies in a sample. ELISA often comes in kit format, with pre-selected antibody pairs to detect specific proteins or biomarkers of diseases such as diabetes and obesity, or cardiovascular and neurological disorders. Detection is made possible with chemiluminescent, fluorescent or colorimetric substrates and detection instruments such as microplate / ELISA readers. Other kits available include: Enzyme-linked immunospot (ELISPOT) assays for the quantification of protein-producing cells and chemiluminescent immunoassays (CLIA) kits. Find the best ELISA kits and products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.BiomarkersBiomarkers are biological markers which can be measured and evaluated to indicate a biological state. The use of biomarkers in research and diagnosis can indicate a normal or disease state or drug response of cells / tissues. Biomarkers include genetic markers, cell surface markers such as antigens, antibodies or receptors and secreted molecules such as cytokines. An assay system is required for identification of biomarkers. :