Millipore’s New Advanced, High-Performance Pellicon® 3 TFF Cassettes with Ultracel PLC 10 and 30 kD Membranes Offer Maximum Reliability and Performance

Millipore today announced the availability of Pellicon® 3 cassettes with Ultracel® PLC membranes. These third-generation Pellicon cassettes are the optimum tangential flow filtration (TFF) device for the filtration of monoclonal antibodies and other therapeutic proteins.

A reliable linear scale-up solution, Millipore’s next generation of TFF devices offer unprecedented performance consistency, durability and ease of use. Manufactured by an automated, computer controlled process, the robust design of Pellicon 3 cassettes can withstand process pressures of up to 80 psi and reverse pressures up to 30 psi. Each cassette incorporates a rigid end cap that protects the membrane surface from impacts and potential damage. The end cap’s integral seals eliminate the need for external gaskets between each device thus simplifying installation. Pellicon 3 devices can be sanitized with 0.5N NaOH at 50°C up to 50 hours.

Millipore’s Ultracel PLC membranes offer low fouling and low protein binding for high product retention, recovery and yield. Ultracel PLC membranes are constructed of a regenerated cellulose membrane cast on a microporous substrate for a uniform, robust structure, with high integrity and greater resistance to back pressure. An automated membrane manufacturing process provides tight control, capability and consistency that produces membranes that provide high yields and retention robustness to all processing conditions and is a critical component to ensuring that the Pellicon 3 cassettes achieve high yields and deliver scalable and reproducible performance.

From small-scale to full-scale production, Pellicon 3 cassettes are designed for use in research, process scale-up/scale-down, applications development and full-scale manufacturing. Available in four sizes (88 cm2, 0.11 m2, 0.57 m2, and 1.14 m2), the design and automated manufacturing process of the Pellicon 3 cassettes provides unbeatable performance consistency and enhanced linear scalability between cassette sizes.

For more information, please contact Millipore Tech Service at 1-800-MILLIPORE or visit the article webpage.