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Menarini Silicon Biosystems launches the MSBiosuite Bioinformatic Platform

Menarini Silicon Biosystems

Cloud-based solution automates NGS data analysis for liquid biopsy and FFPE workflows

19 Sept 2019
Laura Sisman
Administrator / Office Personnel

Product news

Menarini Silicon Biosystems announced the launch of the MSBiosuite, a cloud-based data analysis solution that completes the company workflow* for liquid biopsy and formalin-fixed paraffin embedded (FFPE) tissue analysis; providing a powerful tool to bridge the gap between sequencing data and consolidated results.

The MSBiosuite was developed in partnership with BlueBee, the global genomics data platform company. The newly integrated data solution provides optimized next-generation sequencing (NGS) data processing, analysis, interpretation and reporting for users of Menarini NGS library preparation kits. The solution meets clinical data security and compliance requirements and guarantees data residency within the region of choice.

“We have removed the complexity and high barrier that traditionally exist for bioinformatics, data management, and clinical data compliance and security,” said Fabio Piazzalunga, CEO of Menarini Silicon Biosystems. “With MSBiosuite, we now offer an integrated data solution that completes our single-cell liquid biopsy and FFPE workflows and will support our customers in getting to actionable results with efficiency and confidence.”

MSBiosuite is designed to automate processing of raw sequencing data generated with Ampli1™ and DEPArray™ NGS kits for single circulating tumor cells (CTCs) and FFPE tissue analysis respectively; providing information on copy number profiling and somatic variants.

“Through this partnership, BlueBee enables Menarini Silicon Biosystems to make the data tangible, actionable, and compliant with global health data regulations,” says Hans Cobben, CEO of BlueBee.

A clinical interpretation report is optionally available with the Ampli1 and DEPArray OncoSeek pipelines. Clinically relevant variants are classified by levels of known significance and layers of diagnostic, prognostic, therapeutic and biomarker evidence are integrated. The service also incorporates deep scientific and clinical analysis of each patient’s molecular data, to identify and prioritize the best clinical trial options.

Menarini Silicon Biosystems has also introduced the NGS library preparation kit, Ampli1 OncoSeek Panel for Illumina® platform, which complements Ampli1 LowPass kit for comprehensive single-cell molecular profiling. Ampli1 OncoSeek Panel allows simultaneous detection of single nucleotide variants (SNVs), insertions/deletions (indels) and focal copy number amplification in 60 clinically relevant, oncology-related genes starting from DNA amplified with best-in-class Ampli1 WGA kit.

The MSBiosuite and Ampli1 OncoSeek Panel for Illumina® platforms are now available in Europe and will be available in the United States later this year.

* for research use only. Not for use in diagnostic procedures.


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MSBiosuite

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MSBiosuite is a cloud-based platform for the automated analysis of data generated by the sequencing of libraries obtained with Ampli1™ LowPass Kit, Ampli1™ OncoSeek Panel and DEPArray™ OncoSeek Panel.

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Genome AnalysisGenomics, the study of genomes, includes functional genomics, evolutionary genomics and comparative genomics. There are many genomic technologies such as DNA sequencing of whole genomes, computational biology and bioinformatics. DNA and nucleic acids must be isolated and concentrated from cells for analysis with kits, automated analyzers and software. Other useful technologies for studying genomics include PCR, microarrays and electrophoresis.Data AnalysisData analysis hardware and software is available to make data processing straight-forward yet powerful. Data software can be used for math and stats, technical graphing and image analysis. In addition, software is available for specific data analysis of electrophoresis, densitometry, ELISA and DNA sequencing.Chem / BioinformaticsCheminformatics and bioinformatics are computational techniques used in chemistry and biology, respectively, for data acquisition, processing and storage. Cheminformatics focuses on compound information, whereas bioinformatics is mainly applied to analysis and modeling of genomics, genetic and sequencing information. Hardware and software is available for data acquisition, analysis, management and storage.Sample ManagementSample management systems include sample storage devices such as freezers and plate storers, sample environment enclosures and sample organization, retrieval and sorter systems. Useful system features include high-throughput, automation, robotic arms, automated liquid handling and associated database systems. Accessories in sample management include barcode scanners, heat sealers and tubes.Plate ProcessingAutomated plate processing is used in microplate technologies for high-throughput, speed and efficiency. Plate processing systems include microplate handlers for moving plates, heat sealers, stackers and carousels for storage, retrieval and delivery, microplate washers and piercers. Useful features of plate processors include walk-away automation, compatibility and easy integration with microplate systems.Automated Liquid HandlingAutomated liquid handling equipment is used to mix, dilute and dispense allotted volumes of liquid into microplates and other vessels automatically. The robotic, liquid handling arms can dispense from single channel to 3456 multichannel as well as operate nanoliter dispensing, enabling high throughput of samples. Find the best automated liquid handlers in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Next Generation SequencingNext-generation sequencing (NGS), also known as whole-genome sequencing, high-throughput sequencing and massive parallel sequencing, produces and analyses thousands to millions of nucleotide sequences at once. Sequencing systems operate via varying technologies depending on the manufacturer, including sequencing by synthesis, ligation, pyrosequencing, ion semiconductor and single-molecule real-time sequencing. For NGS, library preparation is paramount to successful sequencing. In this section, explore a range of library preparation kits, from targeted, amplicon-based or hybridization-based kits including epigenomic, transcriptomic and genomic workflows to fragmentation kits. Find the best next-generation sequencing products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Tissue ProcessingTissue processing involves preparing biological tissue samples for microscopic analysis, including fixation, embedding, and sectioning. This process is essential for histopathology and diagnostic applications. Explore tissue processing products in our peer-reviewed product directory; compare products, check reviews, and get pricing directly from manufacturers.AutomationAutomation in laboratories and manufacturing processes enhances efficiency, precision, and scalability by reducing the need for manual intervention. It plays a critical role in improving productivity, minimizing human error, and accelerating workflows in fields like diagnostics, drug development, and industrial testing. Automation technologies include robotic systems, automated liquid handlers, and process control systems that streamline complex tasks and ensure consistent, reproducible results. Explore our peer-reviewed product directory to discover the best automation solutions, compare options, read user reviews, and get prices directly from manufacturers.Data AnalysisThe analysis of data is the process of transforming, modeling and evaluating data to discover useful information from experimental results. Data ManagementGenomicsGenomics is the study of genomes, focusing on the sequencing, analysis, and interpretation of genetic material. It is key in understanding genetic diseases, evolutionary biology, and personalized medicine. Techniques like next-generation sequencing (NGS) are commonly used in genomics research. Browse our peer-reviewed product directory to find the best genomics tools, compare products, check reviews, and get pricing directly from manufacturers.NGS AutomationNGS automation streamlines next-generation sequencing workflows, increasing throughput, accuracy, and reproducibility. Automated solutions enhance productivity in genomic research, clinical diagnostics, and personalized medicine. Browse peer-reviewed tools to compare products, read reviews, and get pricing.Single Cell GenomicsFFPEFormalin-fixed paraffin-embedded (FFPE) tissues are commonly used in medical research, particularly in histology and cancer studies. The preservation process allows long-term storage of tissue samples for later analysis. Explore FFPE research products in our peer-reviewed product directory; compare products, check reviews, and get pricing directly from manufacturers.

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