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Markers for COVID-19 disease progression: Comprehensive LC-MS characterization of the metabolome

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Watch this on-demand webinar to learn about the recently launched Xevo G3 QTof system and discover how it is solving problems that matter

24 Apr 2023
Georgina Wynne Hughes
Editorial Assistant

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Clare Mills, professor of molecular allergology at the University of Manchester, and Dr Jayne Kirk, a principle product manager at Waters
Clare Mills, professor of molecular allergology at the University of Manchester, and Dr. Jayne Kirk, a principle product manager at Waters

If you are wanting to characterize a range of analytes with LC/MS or are interested in high-throughput, benchtop QTof technology to help solve problems in your lab, then you will not want to miss this webinar now available on demand. In this webinar, featuring Dr. Jayne Kirk and Professor Clare Mills, you will learn about the Xevo™ G3 QTof system from Waters and discover how it is solving problems that matter.

Dr. Jayne Kirk, a principal product manager at Waters with over 18 years’ experience in LC/MS instrumentation, technologies, and software, introduces the Xevo G3 QTof, an analytical workhorse for the detailed characterization of biomolecules and processes. Clare Mills, professor of molecular allergology at the University of Manchester, discusses the use of an LC/MS metabolomics approach to profile serum from COVID-19 inpatients, using the Xevo G3 QTof. Professor Mills describes how to identify and characterize prognostic biomarkers to support the development of mass spectrometry rapid clinical screening tools. Watch this webinar to also hear more about characterizing immune dysfunction as a consequence of SARS-CoV-2 infection.

Watch on demand

Discover how the Xevo G3 QTof system provides comprehensive characterization of analytes

The latest generation of the Xevo product line extends the simplicity and range of characterization, from challenging small molecules to complex biotherapeutics. Updates to the ion optics design provide consistent robustness and performance, with incorporation of core technology for comprehensive quantitation capabilities. Centered around an expanding array of informatics tools, Dr. Kirk will explain how the Xevo G3 QTof has your lab covered, and enables complete confidence in your results.

Develop an understanding of LC/MS and its use in metabolomic and lipidomic studies, delve into the world of omics, and learn how to identify statistically relevant markers for disease

Professor Mills explains how the Manchester Allergy, Respiratory and Thoracic Surgery (ManARTS) tissue bank opportunistically collected COVID-19 patient samples, with the aim to understand molecular mechanisms in COVID-19 through LC/MS multiomics approaches – they were able to enroll 420 subjects during the early wave of the pandemic. She then discusses the importance of stratified clinical information in terms of disease severity, as well as excellent mass spectrometry equipment, in biomarker discovery. She then outlines the sample processing protocol, as well as the LC and MS conditions, used in this study. Finally, Professor Mills explains how to identify statistically relevant markers for disease, and discusses the impact on patients.

You can watch the full webinar here>>

SelectScience runs 10+ webinars a month across various scientific topics, discover more of our upcoming webinars>>

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LC-MSLC-MS (liquid chromatography-mass spectrometry) systems and equipment are used for separation and quantitative analysis of complex mixtures, combining liquid chromatography and mass spectrometry. Quantify proteins, contaminants, pesticides or screen for drug metabolites with a high level of sensitivity. LC-MS systems and equipment include reverse phase, normal phase and specialized columns integrated with various MS detectors such as time-of-flight (TOF), quadrupole, orbitrap or ion trap mass analyzers. LC-MS/MS instruments equipped with a qTOF or triple quadrupole analyzer give greater sensitivity and resolving power to your analysis. Find the best LC-MS equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Clinical ChemistryBiochemistry (or clinical chemistry) involves the analysis of bodily fluids using chemical tests. Techniques used include HPLC, chromatography, spectroscopy, mass spectrometry, immunochemical, electrophoresis, turbidometric / spectrophotometric assay, MRI and ISE analysis. Tests are often carried out on plasma or serum but urine (urinalysis) and fecal specimens are also processed.Mass SpectrometryMass spectrometry (MS) is a powerful analytical technique used to identify and quantify molecules based on the mass-to-charge ratio of gas-phase ions. It provides detailed information about the structure, composition, and properties of compounds and is widely used across fields such as environmental monitoring, materials science, drug discovery and development, food and beverage testing, and wider chemical research. Key MS techniques include tandem mass spectrometry (MS/MS), liquid chromatography–mass spectrometry (LS-MS) and inductively coupled plasma (ICP-MS). Choosing from these wide range of techniques and technologies can be a daunting task, so keep up to date with scientific applications, performance expectations, and customer reviews here all in one place. Visit our product directory to receive quotes direct from the manufacturer. ChromatographyChromatography is a powerful technique used to separate and analyze components of mixtures based on their chemical properties. It is widely used in fields like biochemistry, pharmaceuticals, and environmental analysis. By exploiting differences in the interaction of substances with a stationary phase and a mobile phase, chromatography enables precise purification and quantification of compounds. Whether you're working with complex biological samples or industrial chemicals, chromatography is essential for obtaining high-quality results. Browse our peer-reviewed product directory to find the best chromatography systems, compare products, read customer reviews, and get pricing directly from manufacturers.BiotherapeuticsBiotherapeutics are proteins and other compounds (such as nucleic acids) produced by living organisms that have uses as therapeutics or in <i>in vivo</i> diagnostics. The most well-known example of a biotherapeutic product, and the first to be approved for therapeutic use, was recombinant human insulin.

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Markers for COVID-19 disease progression: Comprehensive LC-MS characterization of the metabolome