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Malvern Scientists to Present Emerging Protein Characterization Techniques at Biotherapeutics Analytical Summit

Malvern Panalytical
17 Mar 2014
Sarah Thomas
Associate Editor

Industry news

Dr Wei Qi and Dr Linda Kidder, both senior scientists within Malvern Instruments’ Bioscience Development Initiative, will present work on techniques for protein analysis at the 2014 Biotherapeutics Analytical Summit which takes place in Baltimore MD, USA, from 24-27 March.

The topic of Dr Wei Qi’s poster is ‘Emerging Techniques for Therapeutic Protein Characterization - Viscosity, Stability and Sub-Visible Particles’ while Dr Linda Kidder’s oral presentation on 25 March will discuss ‘Improved Understanding of Association Between Protein Colloidal and Conformation Stability with Combined DLS/Raman’.

A novel approach to protein therapeutics characterization

Dr Kidder will describe how the combination of dynamic light scattering (DLS) and Raman spectroscopy presents a novel approach to protein therapeutics characterization. It enables the simultaneous characterization of protein secondary and tertiary structure, as well as hydrodynamic size, even at high concentrations (> 50 mg/mL), thus enabling the link between colloidal and conformational stability to be more fully understood. She will show some of the new insights and observations that can be gained by applying DLS/Raman to actual biopharmaceutical formulations.

Biopharmaceutical development products on display

Malvern is also pleased to be a sponsor for the summit and will present instruments from the company’s fast-growing analytical toolkit for biopharmaceutical development applications as part of its exhibit on Booth #6. This toolkit encompasses tried and trusted solutions such as Viscotek size exclusion chromatographs to assess product purity and the Zetasizer range for sizing and zeta potential analysis for product stability, as well as groundbreaking new technologies. The Viscosizer 200, for example, is used to assess bioformulation suitability and stability as early as late stage discovery and sits alongside Archimedes and the Nanosight range of Nanoparticle Tracking Analysis instruments to quantify early aggregation in bioformulations.

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ProteomicsProteomics is the systemic bioinformatics study of proteins and amino acids, including their structure, size, function and identification. Tools used in proteomics include chromatography, blotting and gels, protein arrays, mass spectrometry and ELISA and associated analysis software. Analyzers and proteomic systems should be sensitive, high resolution, fast and may be automated for high-throughput.Particle CharacterizationParticle characterization instruments are used to determine particle size distribution, shape, surface area, zeta potential, density and porosity of particles and materials. Multiple tecchniques are available for determining particle size, shape and count including dynamic light scattering (DLS), laser diffraction, electrozone (Coulter technique), imaging particle analysis and single particle optical sensing. Determine the density of your material with a gas pycnometer or examine its surface area and porosity with gas adsorption analyzers and mercury porosimeters. Find the best particle characterization instruments in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Drug DeliveryDrug Delivery refers to dosage form, route of administration, formulations, technologies, and systems for transporting a pharmaceutical compound in the body as needed to safely achieve its desired therapeutic effect. Drug delivery is often approached via the biopharmaceutical or small molecule drug's formulation, but it may also involve medical devices or drug-device combination products. Considerations include instrumentation, software and services. Protein BiologyThe analysis of protein expression, identity and function is vital for many areas of life science research and drug discovery. Some of the most commonly used techniques in protein analysis include Western blotting, electrophoresis and mass spectrometry.BiotherapeuticsBiotherapeutics are proteins and other compounds (such as nucleic acids) produced by living organisms that have uses as therapeutics or in <i>in vivo</i> diagnostics. The most well-known example of a biotherapeutic product, and the first to be approved for therapeutic use, was recombinant human insulin.

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Malvern Scientists to Present Emerging Protein Characterization Techniques at Biotherapeutics Analytical Summit