Malvern<sup>®</sup> SyNIRgi™ in the fight against pharmaceutical counterfeits

14 Nov 2007
Greg Smith
Analyst / Analytical Chemist

Product news

Near infrared chemical imaging (NIR-CI) is proving to be a valuable tool in combating the growing threat posed by pharmaceutical counterfeiting. The SyNIRgi™ system from Malvern® Instruments can rapidly distinguish real from counterfeit products, with limited sample preparation, and often without even the need to remove packaging. Flexible sampling options mean that SyNIRgi can look at capsules, intact tablets, blister packs and powders.

SyNIRgi provides analysis of the nature and spatial location of chemical components within a sample. Combining the species identification capabilities of conventional near infrared spectroscopy with digital imaging, it is ideal for the non-destructive analysis of materials having spatially complex arrangements of chemical species. This applies especially to pharmaceutical products.

Depending on the choice of operating conditions, multiple samples can be compared simultaneously. Alternatively, detailed compositional information can be obtained and compared from individual samples.

The SyNIRgi’s large field of view allows side-by-side comparison of real and suspect products. Furthermore, the ability to put both real and suspect samples in the same image replaces the need to run calibration data on the genuine products. Analysis can be complete in minutes.

Visit the Article Webpage to download recent publications about NIR-CI for counterfeit products analysis

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Near Infrared SpectroscopyNear-infrared (NIR) spectroscopy measures the interaction of near-infrared light with a sample, including transmission, reflectance and absorbance, facilitating the identification of analytes. Measurements can be conducted using a Fourier-transform near infrared (FT-NIR) spectrometer, while there are also UV-Vis- NIR spectrophotometers that measure a broader spectrum of wavelengths. Find the best NIR spectroscopy products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Medicinal ChemistryMedicinal chemistry is a broad discipline encompassing the design, identification, synthesis and development of chemicals in drug discovery. It includes a number of techniques covering structural biology, synthetic chemistry and molecular biology. Technologies used in medicinal chemistry include ADME, lab-on-a-chip, high content screening and assay assembly.Process ChemistryProcess chemistry is an important stage of drug development for scaling-up drug production or chemical synthesis reactions. It is useful for optimizing economical and efficient drug production. Process chemistry uses reactors and pump systems as well as reagents, standards and buffers.Light MicroscopyLight microscopes or optical microscopes are used to visualize microscale objects under magnification, including cells, clinical specimens and materials. Lab equipment for light microscopy includes confocal microscopes, fluorescence microscopes, zoom and stereo microscopes. Microscope slides and imaging reagents are available for visualizing samples, as well as various microscope stages and incubators for large or temperature-sensitive samples. Find the best light microscopes in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.
Malvern<sup>®</sup> SyNIRgi™ in the fight against pharmaceutical counterfeits