Malvern<sup>®</sup> Instruments makes invited contribution to Indian Pharmaceutical Association symposium

23 Sept 2007
Greg Smith
Analyst / Analytical Chemist

Product news

Dr Paul Kippax, product manager for diffraction systems at Malvern® Instruments, is one a of a group of international speakers who will present at the Indian Pharmaceutical Association’s symposium on Advances in Pulmonary and Nasal Drug Delivery, to be held on 4-5 October 2007 at the Hyatt Regency Hotel in Mumbai. In a talk entitled ‘Applying light scattering techniques to the characterization of nasal sprays and inhalers’ he will discuss the use of laser diffraction particle size analysis.

The rapid data acquisition rate achievable using laser diffraction for particle and droplet size analysis enables the capture of time-resolved measurements over a very wide size range. This makes it highly valuable for studying the device and formulation parameters affecting particle formation and dispersion. Applying this data to product development will be a key focus of the talk.

The Spraytec™ system from Malvern Instruments uses laser diffraction to measure particle size distributions and is widely used in the pharmaceutical industry for the analysis of nasal sprays and inhalers. Its ability to deliver real-time, high-speed measurements at an acquisition rate of up to 10 kHz enables the drug delivery profiles from different devices to be captured in exceptional detail. This rapid means of screening is highly complementary to established techniques such as cascade impaction, offering valuable insights into the processes of particle formation and dispersion during inhaler and nasal spray operation.

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Medicinal ChemistryMedicinal chemistry is a broad discipline encompassing the design, identification, synthesis and development of chemicals in drug discovery. It includes a number of techniques covering structural biology, synthetic chemistry and molecular biology. Technologies used in medicinal chemistry include ADME, lab-on-a-chip, high content screening and assay assembly.Particle CharacterizationParticle characterization instruments are used to determine particle size distribution, shape, surface area, zeta potential, density and porosity of particles and materials. Multiple tecchniques are available for determining particle size, shape and count including dynamic light scattering (DLS), laser diffraction, electrozone (Coulter technique), imaging particle analysis and single particle optical sensing. Determine the density of your material with a gas pycnometer or examine its surface area and porosity with gas adsorption analyzers and mercury porosimeters. Find the best particle characterization instruments in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.