SelectScience
Join Free
Accelerating Science
NewsSpectroscopy

Malvern Instruments Presents New Protein Analysis Technique at Two European Conferences

Malvern Panalytical
2 Oct 2013
Liam McNair
Administrator / Office Personnel

Industry news

Malvern Instruments will sponsor and attend two upcoming protein conferences in Europe, showcasing Malvern technology and presenting new research on the innovative combination of Dynamic Light Scattering (DLS) and Raman spectroscopy for protein analysis.


The company will exhibit at PSDI – Protein Structure Determination in Industry - Lucerne, Switzerland, 3-6 November, and PEGS, the Protein & Antibody Engineering Summit (PEGS) Europe 2013 in Lisbon, 4-8 November. Technical specialists will deliver ‘Advances in the Integrated Measurements of Higher Order Protein Structure and Size’ at both events’.

‘Advances in the Integrated Measurements of Higher Order Protein Structure and Size’ explores how combined Zetasizer dynamic light scattering (DLS) and Raman spectroscopy can be used in tandem to offer fresh insights into key protein behaviors, such as aggregation. Aggregation is a perennial issue within biopharmaceutical development, where the tendency of proteins to aggregate may stimulate problematic immune responses in recipients. By combining DLS and Raman spectroscopy into a unified platform, it is possible to correlate a physical change in size with a chemical change, offering unique insights into protein aggregation, as well as non-destructive measurement of a number of thermodynamic and physiochemical protein properties.

Malvern offers a variety of protein characterization solutions. These include the highly successful Zetasizer systems, the Zetasizer Nano ZSP providing top-of-the-range dynamic light scattering technology with a unique specification for protein measurement. The addition of Raman spectroscopy will increase the Zetasizer’s capacity for analysis, which now extends to electrophoretic, spectral and microrheological characterization of protein species.

Links

Malvern PanalyticalCompany website

Tags

Raman SpectroscopyRaman spectroscopy is used to discern the vibrational and rotational states of molecules and hence the chemical composition of a sample by measuring the inelastic scattering of monochromatic light. Explore a range of Raman spectrometers, including handheld/portable Raman spectrometers for QC/QA labs and in situ spectrometers for processes. Conduct Raman imaging for microanalysis of mixed samples using a Raman microscope. Raman spectrographs are also available. Find the best Raman spectroscopy products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.ProteomicsProteomics is the systemic bioinformatics study of proteins and amino acids, including their structure, size, function and identification. Tools used in proteomics include chromatography, blotting and gels, protein arrays, mass spectrometry and ELISA and associated analysis software. Analyzers and proteomic systems should be sensitive, high resolution, fast and may be automated for high-throughput.Particle CharacterizationParticle characterization instruments are used to determine particle size distribution, shape, surface area, zeta potential, density and porosity of particles and materials. Multiple tecchniques are available for determining particle size, shape and count including dynamic light scattering (DLS), laser diffraction, electrozone (Coulter technique), imaging particle analysis and single particle optical sensing. Determine the density of your material with a gas pycnometer or examine its surface area and porosity with gas adsorption analyzers and mercury porosimeters. Find the best particle characterization instruments in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Protein BiologyThe analysis of protein expression, identity and function is vital for many areas of life science research and drug discovery. Some of the most commonly used techniques in protein analysis include Western blotting, electrophoresis and mass spectrometry.Particle Size AnalysisParticle size analysis describes the size distributions from sub-nanometer to millimeter of particulate samples. Size is an important physical property and the technique is often utilized in a range of industries, such as chemical, environmental and agriculture.Dynamic Light ScatteringDynamic light scattering is used to measure the size distribution of particles in suspension by analyzing the way light scatters off them. It is commonly used in materials science, nanotechnology, and protein characterization. Browse our peer-reviewed product directory to find the best dynamic light scattering systems, compare products, check reviews, and get pricing directly from manufacturers.

Related articles

Malvern Instruments Presents New Protein Analysis Technique at Two European Conferences