Malvern Adds New Applications to Market-Leading GPC/SEC System

26 Apr 2010
Sarah Sarah
Marketing / Sales

Product news

Malvern Instruments has extended the applications for its Viscotek Triple Detector Array (TDA), the multi-detector platform for gel permeation/size exclusion chromatography (GPC/SEC), through the inclusion of a new viscometer in the setup. The TDA maximises the productivity of GPC/SEC analysis by simultaneously measuring absolute molecular weight, molecular size and intrinsic viscosity. The new viscometer combines unrivalled sensitivity with an innovative 316 stainless steel transducer construction that offers excellent chemical resistance. It therefore provides the most precise intrinsic viscosity and structural information for an expanded range of biomolecules, natural and synthetic polymers.

The unique viscometer design uses digital inert transducer technology to give a faster, more sensitive response to viscosity changes than traditional transducers. Its 316 stainless steel construction means that there are now few limitations, in terms of salt content or pH, on the chromatographic conditions that can be used. This is a significant benefit for protein analysis. The use of inert capillaries in the measuring flow path is also advantageous for many biomolecule applications.

The TDA lies at the heart of the Viscotek TDAmax: a complete, advanced GPC/SEC system suitable for all macromolecular applications. However, each element of the TDA can be purchased alone or in combination, offering exceptional flexibility to those with existing GPC/SEC systems. UV and/or PDA detectors are also available to further augment detection capabilities. These are especially useful for the analysis of composition for copolymers and/or conjugated proteins.

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Size Exclusion ChromatographySize exclusion chromatography (SEC) is a liquid chromatographic technique used to separate and identify molecules based on their size, including polymers, proteins, nanoparticles & nucleic acid. SEC is further subdivided into gel filtration chromatography (GFC) and gel permeation chromatography (GPC) when an aqueous or organic mobile phase is used respectively. HPLC-based SEC systems and columns are available for analytical separation alongside SEC spin columns or filters to prep samples for many protocols. Find the best size exclusion chromatography equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.UV-Visible SpectroscopyUltraviolet-visible (UV-Vis) spectrophotometers are used to measure the interaction of UV and visible light with a sample, including transmission, reflectance & absorbance. The two major instrument classes are single-beam or double-beam spectrophotometers. More specialized equipment includes colorimeters, spectroradiometers and refractometers. Portable and microvolume spectrophotometers are also available. For the modular spectroscopy lab, explore a range of light sources for combination with a spectrograph/spectrometer and optics. Find the best UV-Vis spectroscopy products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.ProteomicsProteomics is the systemic bioinformatics study of proteins and amino acids, including their structure, size, function and identification. Tools used in proteomics include chromatography, blotting and gels, protein arrays, mass spectrometry and ELISA and associated analysis software. Analyzers and proteomic systems should be sensitive, high resolution, fast and may be automated for high-throughput.Gel Doc / Image AnalysisGel documentation (gel doc) or gel imaging systems are used for the analysis of proteins, antibodies and nucleic acid immobilized in polyacrylamide or agarose gels, membranes or microarrays. Explore a range of a gel imaging systems, densitometers, scanners, transilluminators or UV lamp + CCD cameras for your image analysis solutions. Colorimetric, fluorescent and/or radioisotopic samples can be visualized and documented for further analysis. See gel doc / Image analysis software for quantitative 1D and 2D analysis of your samples. Find the best gel doc / image analysis products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.