Low Adsorption Sample Vials for LC/MS/MS

Waters Corporation has introduced TruView LCMS Certified Vials, a new line of low-adsorption sample vials certified for LC/MS/MS analyses where analyte concentrations are in the order of ng/mL or pg/mL and where analytical sensitivity and accuracy are critical.

"As LC/MS/MS technology evolves and levels of detection approach or exceed the part-per-trillion range, our customers are demanding low adsorption vials that won’t compromise their results,” said Mike Yelle, Senior Director, Chemistry Commercial Operations, Waters Division. “Our TruView glass vials are manufactured and certified to perform better than any commercially available glass autosampler vial.”

TruView vials are manufactured under tight controls using a proprietary process that limits the concentration of free ions on the surface of the glass lowering analyte adsorption. Normally during the manufacture of glass vials, free ions are deposited on the surface. Problems occur when the ions are freed from the surface and enter the sample raising the pH and exposing ion exchange sites on the glass to sample analytes that can bind to the glass. The longer a vial awaits aspiration and injection of its contents, the greater the analyte adsorption.

The clear glass vials are made from Type I, 33 expansion glass, with very low free ion content. They are held to tight dimensional tolerances to avoid damage to the needle or instrument. The caps/septums have been tested by head space GC to ensure proper curing of the silicone polymer. Finally the cleanliness has been tested by HPLC using a Symmetry® Column run in a gradient mode, UV detection with the data captured and processed using Empower™ Software.