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Life Technologies’ 3500 Dx Series Genetic Analyzer Now Available in South Pacific

Thermo Fisher Scientific
7 Jul 2010
Sarah Sarah
Marketing / Sales

Product news

Life Technologies Corporation announces that its Applied Biosystems™ 3500 Dx Series Genetic Analyzers, the first CE IVD- marked capillary electrophoresis system for nucleic acid analysis** designed to comply with Directive 98/79/EC on IVD medical devices, are now available in Australia, India, New Zealand, Singapore, and Taiwan.

The 3500Dx Series Genetic Analyzers are now approved by the Singaporean and Taiwanese regulatory authorities and the current IVD policies of Australia, New Zealand, and India allow the system to enter into commercial distribution in these countries. These additional nations join 13 European countries that will now benefit from this sequencing platform, including Austria, Belgium, Finland, France, Germany, Italy, Luxembourg, the Netherlands, Norway, Spain, Sweden, Switzerland, and the United Kingdom.

The 3500 Dx Series Genetic Analyzers are intended for use in the analysis of human DNA or RNA for the detection of genetic changes that may lead to disease presence or susceptibility and designed with a number of enhancements for improved data quality as well as easier to use Data Collection Software. Consumables, such as POP-7™ polymer, buffers and capillary arrays utilize radio frequency identification (RFID) technology, which allows the Data Collection Software to monitor and store data for consumables, such as lot and part numbers, as well as consumables usage and other important information. This makes the system robust, easy-to-use and less prone to manual errors. Several medical institutions studying a number of critical human diseases such as cancer are currently using the 3500 Dx Series System for such analysis.

“As additional countries approve the 3500 Dx Genetic Analyzer as an IVD medical device, more important genetic sequences that aid in combating critical human diseases like cancer will be identified,” said Ben Hwang, head of the Asia Pacific region for Life Technologies. “It is evident that there is a commitment to advancing human health as countries continue to recognize the value of a system like the 3500 Dx Series. This genetic analyzer will help make the promise of personalized medicine a reality.”

The 3500 Dx Series Genetic Analyzers are part of a broader portfolio of advanced genomic technologies that are built upon Applied Biosystems legacy of providing platforms that are recognized for proven technology, reliability and performance. They provide an integrated solution that combines the instrument with Applied Biosystems reagents, consumables, software, service and support.

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ElectrophoresisElectrophoresis equipment is used to separate mixtures of protein, DNA or RNA, based on their electric charge, size and other physical characteristics, by passing them through a medium such as a polyacrylamide gel, an agarose gel or a capillary tube. Electrophoresis equipment includes horizontal and vertical gel electrophoresis chambers, isoelectric focusing systems, 2D electrophoresis and capillary electrophoresis instruments. Precast gels with a gradient can be used or gels can be hand cast. Samples are run alongside ladders or markers to identify the approximate size of a molecule. Separated proteins and nucleic acids in the gel can be stained or probed with fluorescent markers and then imaged and detected using gel documentation instruments, transilluminators, densitometers and scanners. Find the best electrophoresis equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Genome AnalysisGenomics, the study of genomes, includes functional genomics, evolutionary genomics and comparative genomics. There are many genomic technologies such as DNA sequencing of whole genomes, computational biology and bioinformatics. DNA and nucleic acids must be isolated and concentrated from cells for analysis with kits, automated analyzers and software. Other useful technologies for studying genomics include PCR, microarrays and electrophoresis.ProteomicsProteomics is the systemic bioinformatics study of proteins and amino acids, including their structure, size, function and identification. Tools used in proteomics include chromatography, blotting and gels, protein arrays, mass spectrometry and ELISA and associated analysis software. Analyzers and proteomic systems should be sensitive, high resolution, fast and may be automated for high-throughput.DNA / RNA Extraction and PurificationPurified DNA and RNA are required for numerous downstream molecular biology applications. Consequently, the importance of high-quality DNA/RNA extraction and purification equipment cannot be underestimated. Many purification kits are available and are typically optimized for nucleic acid type and source, including plasmid DNA, genomic DNA, mRNA, RNA and viral nucleic acid purification kits. Automated extraction and purification of nucleic acids can be implemented with magnetic bead separator instruments or high-throughput purification workstations. Find the best DNA/RNA extraction and purification equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.RNA InterferenceRNA interference (RNAi) uses siRNA or miRNA for transcriptional silencing, gene knockdown and regulation of gene expression. RNAi requires chemical synthesis, introduction of DNA vectors into cells, an assay of RNAi effects and RNAi quantification or analysis. Consider target sequence selection, reagent preparation, controls, high specificity and effectiveness and low non-specific gene knockdown.

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