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Late-Breaking Abstract from NBE-Therapeutics to Debut at AACR

NBE Therapeutics
14 Mar 2019
Matthew Horan
Consultant

Industry news

NBE-Therapeutics AG, a biopharmaceutical company developing next-generation, immune-stimulatory antibody-drug conjugates (iADCs) for improved cancer therapy, has announced that it will present a late-breaking abstract at the Annual Meeting of the American Association for Cancer Research (AACR) to be held from March 29 - April 3, 2019 in Atlanta, Georgia, U.S. (abstract number LB-197). The title of the late-breaking abstract selected by AACR is: "NBE-002, an anthracycline-based immune-stimulatory antibody drug conjugate (iADC) targeting ROR1 for the treatment of triple-negative breast cancer". The abstract discusses the profound in vivo anti-tumor efficacy of NBE's lead iADC program, NBE-002, in preclinical, patient-derived triple-negative breast cancer models over a wide range of ROR1 expression levels, as well as the potent immune-oncology function of NBE's iADC platform.

A poster will be presented in the Immunology session at AACR on:

Date: Tuesday April 2, 2019
Time: 8:00am to 12:00pm
Abstract number: LB-197

The NBE team will present the detailed data to industry stakeholders at a workshop from 06:30 to 8:00 p.m. on the same day. Participation in the event is by invitation only.

“This late-breaking abstract shows the continuous innovation at NBE-Therapeutics and is an exciting demonstration of the best-in-class long-lasting anti-tumor efficacy of NBE-Therapeutics' iADC platform in one of oncology`s most challenging fields of triple-negative breast cancer”, said Roger Beerli, NBE`s Chief Scientific Officer.

NBE develops next-generation iADCs based on its proprietary, site-specific SMAC-Technology™ and a novel highly potent anthracycline-based toxin platform. NBE has the objective to develop first- and best-in-class ADC product candidates against tumor targets in cancer indications of high unmet medical need. Its first lead candidate NBE-002 is forecasted to enter clinical trials in 2020.

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AntibodiesAntibodies are used in techniques such as confocal and fluorescence microscopy, flow cytometry, ELISA, ELISPOT, immunohistochemistry, western blotting and immunopreciptation. Select specific antigen reactivity, high specific affinity, low non-specific binding, monoclonal or polyclonal, primary or secondary antibodies and associated conjugates such as an enzyme or dye for visualization.ELISAEnzyme-linked immunosorbent assays (ELISA), also known as enzyme immunoassays (EIA), are used for the detection and quantification of proteins, peptides and antibodies in a sample. ELISA often comes in kit format, with pre-selected antibody pairs to detect specific proteins or biomarkers of diseases such as diabetes and obesity, or cardiovascular and neurological disorders. Detection is made possible with chemiluminescent, fluorescent or colorimetric substrates and detection instruments such as microplate / ELISA readers. Other kits available include: Enzyme-linked immunospot (ELISPOT) assays for the quantification of protein-producing cells and chemiluminescent immunoassays (CLIA) kits. Find the best ELISA kits and products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Antibody Drug ConjugatesAACRThe American Association for Cancer Research (AACR) is a leading organization focused on cancer research and treatment. It provides a platform for scientists, healthcare professionals, and industry leaders to share knowledge and collaborate in the fight against cancer.

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Late-Breaking Abstract from NBE-Therapeutics to Debut at AACR