Lab901 Announces True at-Line Monitoring of Monoclonal Antibody Production by SDS-PAGE

Lab901 announced at the Peptalk 2010 conference that its Protein ScreenTape® platform can deliver, for the first time, true, practical at-line monitoring of monoclonal antibody production. Before now, at-line monitoring of antibody production by SDS PAGE has been impractical with other existing platforms as the cost per test-point is too high or the analysis takes too long to be of value.

With its rapid staining protocol and automated sample handling, electrophoresis and data presentation, the Protein ScreenTape platform can deliver information on yield, purity and molecular weight within a few minutes. Samples can be analysed directly from the bioreactor with no need to purify or filter the media. Analysis of media containing high levels of serum is also possible using ScreenTape. Lab901 application scientist Adam Inche said, “This information will be invaluable not only for process optimisation, but also for batch monitoring as it is now possible to assess antibody production by SDS-PAGE on a day-by-day, or even hour-by-hour basis. This data will enable our clients to make more informed decisions on when to harvest their bioreaction batch, thus saving time and money.”