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Kapa Biosystems Introduces PROBE FORCE- an Amplification-free qPCR Master Mix for Challenging Sample Types

Kapa Biosystems, Inc.
25 Aug 2015
Chelsie Phillips
Temporary Editorial Assistant

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Kapa Biosystems announced the introduction of KAPA PROBE FORCE, a highly inhibitor resistant qPCR master mix that removes the need for DNA purification, enabling streamlined sample-to-quantitation in less than an hour.

The master mix contains a high-performance engineered DNA polymerase enzyme specially designed to overcome blood, tissue, and plant PCR inhibitors. With KAPA PROBE FORCE, crude samples can now be analyzed with comparable accuracy, reproducibility, and sensitivity as purified DNA. The product is designed for low- or high-throughput genotyping, as well as gene expression studies.

“KAPA PROBE FORCE is ideally suited for direct qPCR analysis of challenging sample types without the need for purification,” said Charles Joseph, Global Product Manager, qPCR at Kapa Biosystems. “Customers can create streamlined, cost-effective workflows designed to fit any budget, without compromise.”

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KAPA PROBE FORCE qPCR Kits

Kapa Biosystems, Inc.

KAPA PROBE FORCE is a highly inhibitor resistant qPCR master mix that removes the need for DNA purification, enabling streamlined sample-to-Cq workflows. The master mix contains a third generation DNA polymerase evolved to overcome blood, tissue, and plant PCR inhibitors. Crude samples can now be analyzed with comparable accuracy, reproducibility, and sensitivity as purified DNA using KAPA PROBE FORCE.   Features:   Streamline sample-to-Cq workflows  in <1 hour. Eliminate the time and cost of sample purification by amplifying directly from crude samples. Analyze a wide range of sample types including  whole blood,  cells, mouse tails, FFPE, leaf, stem, seed, and soil. Generate accurate and reproducible results. Kits include a third-generation DNA polymerase, evolved for robust target amplification and detection. Enzyme maintains high reaction efficiency in the presence of PCR inhibitors for reliable data generation. Break through high levels of qPCR inhibitors. Achieve greater levels of sensitivity  for inhibited blood, tissue, and plant samples. Convert purified DNA assays to crude workflows without observable Cq delays. Multiplex crude samples efficiently. Accelerate genotyping analysis with single reaction allelic discrimination of crude DNA extracts. Maximize data collection from precious samples, increase throughput, and reduce costs.   Applications: GMO testing. Mouse transgenics. SNP genotyping. Food/water pathogen detection. Infectious disease research. Cancer research.

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PCR and Thermal CyclingPolymerase chain reaction (PCR) kits and thermal cyclers are used for the in vitro amplification of DNA permitting subsequent analysis and experimental procedures. Explore a range of high-quality polymerase, primers and nucleotides or simplify your workflow with a PCR mastermix. Find reverse transcription PCR (RT-PCR) and cDNA synthesis kits for RNA products and libraries. Quantitatively measure the amplification of DNA with real-time PCR (qPCR) and droplet digital PCR (ddPCR) kits and systems, and discover automated PCR setup solutions to increase throughput. Alternative DNA amplification methods also include recombinase polymerase amplification (RPA) kits. Find the best PCR kits and thermal cyclers and purification equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.DNA SequencingDNA sequencing, such as sanger sequencing, is a biological technique that determines the precise order of nucleotide bases in a fragment or template of DNA. DNA sequencers and genetic analyzers are based on capillary electrophoresis, where labeled DNA fragments are electrophoretically separated by size as they migrate through a polymer. Find the best DNA sequencing products, including DNA sequencing kits, genomic libraries and genetic identity kits in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.DNA / RNA QuantificationDetection and quantification of nucleic acids is important in molecular biology, cloning, expression, forensics and clinical diagnostics. Nucleic acids can be detected by labeling with colorimetric, fluorescent or radio labels and using in situ hybridization kits to identify specific sequences. Multiple nucleic acids can be detected and quantified at once using RNA / DNA detection beads or RNA / DNA microarrays. Find the best DNA / RNA Quantification products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.qPCRQuantitative PCR (qPCR) is a molecular biology technique used to amplify and measure the amount of a specific DNA or RNA target. It plays a crucial role in gene expression analysis, pathogen detection, and quantifying DNA or RNA in various applications. Real-time PCR provides precise, quantitative results and is widely used in research, diagnostics, and clinical studies. Browse our peer-reviewed product directory to find the best qPCR solutions; compare products, check reviews, and get pricing directly from manufacturers.

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Kapa Biosystems Introduces PROBE FORCE- an Amplification-free qPCR Master Mix for Challenging Sample Types