iSOFT Announces Hospital Project to Extract Clinical Information for Research Use

1 Mar 2012
Sonia Nicholas
Managing Editor and Clinical Lead

Product news

iSOFT, a CSC company, has announced that it is to join forces with University Hospital Southampton NHS Foundation Trust, UK, to explore using new software to extract and make anonymous, clinical information for research and clinical trials.

“Clinical information held by NHS trusts is of huge value in clinical research and offers these trusts a potential income stream,” said Dr Joerg Kraenzlein, iSOFT’s director of life sciences. “A key goal is to prove that our solution is able to extract a broader range of clinical information than is currently possible and at a fraction of the time and cost.

“Current methods normally involve trawling through records manually, which is time consuming and unreliable as records are often missed or lack relevance. The project will potentially save months in the planning and execution phase of clinical trials,” Kraenzlein said.

During the project, CliniWorks AccelFind software will be interfaced to Southampton’s clinical systems to extract and de-identify information about cancers, heart and blood conditions, and other diseases from one million records. It will also collect and structure information on diagnoses, treatments, medications and outcomes into a format that supports research and clinical trials.

Adrian Byrne, Southampton’s chief information officer, said: “Southampton is already a leader in involving patients in research programmes and we are happy that we can work with iSOFT to improve this and ensure that more patients obtain access to the latest and best treatments.”

iSOFT signalled its intent to move into the life sciences space, after agreeing a deal with US-based CliniWorks for AccelFind, which is developed to extract medical knowledge from any type of data, including free text notes, discharge summaries or the structured data found in electronic medical records.

“Drug development is an extremely expensive business and typically costs up to US$1 billion to bring a single drug to market,” Kraenzlein said.

“The process of recruiting patients for clinical trials is the most critical element, causing 80% of trials to run over time and budget, with an average of 90 days and £1.3 million in lost sales, so anything that reduces time and cost will interest pharmaceutical companies greatly.

“Through our partnership with Southampton and CliniWorks, we can move to developing solutions which will speed the feasibility and patient recruitment processes and so help execute trials on time and budget.”

iSOFT’s chief medical officer, Dr Michael Dahlweid, said: “This is a beacon project which paves the way for healthcare organisations to move beyond collecting data for use during patient care, to using the data for advanced analysis, prediction and improved drug discovery. The potential benefits to patients are significant.”

Tags

Genome AnalysisGenomics, the study of genomes, includes functional genomics, evolutionary genomics and comparative genomics. There are many genomic technologies such as DNA sequencing of whole genomes, computational biology and bioinformatics. DNA and nucleic acids must be isolated and concentrated from cells for analysis with kits, automated analyzers and software. Other useful technologies for studying genomics include PCR, microarrays and electrophoresis.Lab-on-a-ChipLab-on-a-chip (LOC) technology uses microfluidic chips, such as microarrays, to perform biochemical assays on a small scale. Benefits of lab-on-a-chip include the small volume of sample required as well as the speed of analysis. In selecting lab-on-a-chip devices consider the assay, cost, reliability, sensitivity and signal to noise ratio.ProteomicsProteomics is the systemic bioinformatics study of proteins and amino acids, including their structure, size, function and identification. Tools used in proteomics include chromatography, blotting and gels, protein arrays, mass spectrometry and ELISA and associated analysis software. Analyzers and proteomic systems should be sensitive, high resolution, fast and may be automated for high-throughput.Data AnalysisData analysis hardware and software is available to make data processing straight-forward yet powerful. Data software can be used for math and stats, technical graphing and image analysis. In addition, software is available for specific data analysis of electrophoresis, densitometry, ELISA and DNA sequencing.LIMSLIMS (Laboratory Information Management System) is an informatics software system used to improve the quality assurance and quality control (QA / QC) of data management. LIMS can be a standard for common lab workflows, such as commercial off the shelf systems (COTS), or customized for more specialized lab use. Systems are available for mainframe computers or PC.MicrobiologyMicrobiology is the study of microorganisms including protists, prokaryotes, fungi, and, often, viruses. Microorganisms are a useful research tool as genetic vectors and, in immunology, for antibiotic susceptibility testing, cellular biology and genetics. Microorganisms commonly grow readily in incubators with microbial culture media; this can contain chromogenic supplements to differentiate between cell lines. Estimate your culture’s density of microorganisms with colony counters, or screen and select colonies for desirable clones with automated colony pickers. Additionally, equipment is available to monitor environments for the presence of microbes and identify with microbial identification instruments. Find the best microbiology products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Chem / BioinformaticsCheminformatics and bioinformatics are computational techniques used in chemistry and biology, respectively, for data acquisition, processing and storage. Cheminformatics focuses on compound information, whereas bioinformatics is mainly applied to analysis and modeling of genomics, genetic and sequencing information. Hardware and software is available for data acquisition, analysis, management and storage.Data MiningData mining is an important process for extracting information, patterns and trends from data. Data mining software, databases, reference materials and storage packages are available to process lab data.Medicinal ChemistryMedicinal chemistry is a broad discipline encompassing the design, identification, synthesis and development of chemicals in drug discovery. It includes a number of techniques covering structural biology, synthetic chemistry and molecular biology. Technologies used in medicinal chemistry include ADME, lab-on-a-chip, high content screening and assay assembly.Blood TransfusionBlood Transfusion involves giving donor blood to a recipient patient. Screening is essential to avoid transfusion reactions. Blood banks use immunohematological techniques to determine rh and ABO blood group, and screen for antibodies using specific antisera. Blood Banks use Direct Coombs Tests (DCT) and Indirect Coombs Tests (IAT) to detect hemolysis and Haemolytic Disease of the Newborn (HDN).HematologyIn Haematology / Hematology, complete blood cell counts (or full blood counts) are obtained using automated blood count analyzers to enumerate blood cell types.  Hematology also encompasses haemostasis and coagulation, thrombophilia and hemophilia, plasma viscosity and ESR analysis, hemoglobinopathies, cell morphology and haematinic measurement.ImmunologyImmunological techniques measure and characterize immune responses. Immunology kits and analysis systems often use techniques such as ELISA, radioimmunoassay (RIA) and immunodiffusion assays, Immunohistochemistry, and flow cytometry. Immunologists use equipment such as flow Cytometers, plate readers, plate washers and fluorescent microscopes.Cellular PathologyCellular Pathology deals with the microscopic analysis of tissue samples and cells. Sample preparation and processing includes fixation, staining, sectioning and slide mounting, using equipment such microtomes and cryostats. In choosing immunohistochemistry and immunocytochemistry kits, consider chromogens, staining method, antibodies, microscopes and imaging.Point-of-CarePoint-of-Care Testing (POCT) or Near Patient Testing (NPT) products are available for urine, blood and other clinical chemistry analyses. POCT includes: blood glucose testing, blood gas and electrolytes analysis, rapid coagulation testing (PT / INR), rapid cardiac markers diagnostics, drugs of abuse screening, urine strips testing, pregnancy testing, fecal occult blood analysis, food pathogens screening, hemoglobin diagnostics, infectious disease testing and cholesterol screening.Gene Expression and Molecular CloningMolecular cloning is a set of techniques that utilizes vectors to transfer recombinant DNA into host cells and is an essential tool for investigating the expression of genes and proteins in bacterial or mammalian cells. A variety of vectors optimized for gene cloning and expression in a range of host organisms are available, alongside competent cells for genetic replication. Here, you can explore a range of molecular tools, high-quality genomic and cDNA libraries, premade clones, transformation and transfection reagents and mutagenesis or gene expression detection assays and expression arrays. Find the best gene expression and molecular cloning products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.
iSOFT Announces Hospital Project to Extract Clinical Information for Research Use