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Irvine Scientific Introduces Chemically-Defined Dendritic Cell Culture Medium for Immunotherapy Applications

Irvine Scientific

Dendritic cells are a key contributor to developing cancer vaccines

18 Sept 2017
jessica corsino
Marketing / Sales

Product news

Irvine Scientific, a world leader in cell culture media development and manufacture has announced the introduction of PRIME-XV® Dendritic Cell Maturation CDM, a chemically-defined, animal component-free medium for the differentiation of monocytes into immature dendritic cells, and subsequent maturation in dendritic cells.

Current approaches to immunotherapy include harnessing the power of the body’s immune system to treat tumors with cell therapies. One approach is through vaccination, a method where an antigen together with an adjuvant stimulates the body to create therapeutic T cells. Dendritic cells (DCs) are the most potent antigen-presenting cells capable of priming naïve T cells and are therefore essential tools in the activation of immune responses to tumors. They can be generated in vitro from CD14+ peripheral blood or cord blood monocytes through a maturation process. It is essential for these monocyte-derived DCs (Mo-DCs) to maintain their functional capacity of the launching antigen-specific immunity, leading to T cell activation into therapeutic T cells. Serum and undefined components found in animal- or human-derived raw materials can negatively affect this Mo-DC functional capacity. PRIME-XV Dendritic Cell Maturation CDM provides a robust method for the generation of Mo-DCs in chemically-defined culture conditions, thereby maintaining their capacity to induce T cell response.

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“Our continuous research on the effects of components in media has produced convincing data that culturing cells in chemically-defined conditions improves the ability to reliably produce populations of cells that maintain desired functionality and morphology compared to culture media containing animal-derived components.” said Jessie H.-T. Ni, Chief Scientific Officer, Irvine Scientific. “Chemically-defined media also reduces the risk of introducing foreign agents or impurities from undefined components, thereby facilitating scale-up to commercial production and the regulatory submission process.”

PRIME-XV Dendritic Cell Maturation CDM is the ideal complement to PRIME-XV T Cell CDM, the first commercially available chemically-defined medium for T cell culture. Together they provide a complete workflow free from the variability and risk of contamination that the use of animal-derived components presents. All products are manufactured using stringent raw material qualification and under Current Good Manufacturing Practices (cGMP) for consistency and reliability.

Contact Irvine Scientific here for more information about the PRIME-XV products.

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Cell / Tissue CultureCell culture or tissue culture is used to study the biology of cells or tissues and to isolate cellular products in an environment which can be manipulated and well defined. Accurately control your culture environment with bioreactors or culture incubators, bind your cells to a surface or together with an extracellular matrix. Distinguish cell types with differential media or proliferate cells with certain characteristics using selective media. Enrich your media with supplements such as growth factors, sera and vitamins. Find the best cell and tissue culture products, kits and equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Cell Lines Stem Cells and Primary CellsPrimary cell cultures, established cell lines and stem cells are vital for <i>in vitro</i> and <i>ex vivo</i> experimentation. High-quality cells, optimized for your applications, alongside optimized cell substrates, growth medium and supplements, are critical for experimental success. Explore a range of cells suitable for your applications, including isogenic cell lines, competent cells, induced pluripotent stem cell (iPSC)-derived cell lines, fungal/bacterial/mammalian cell lines, stem cells and cancer cell lines. Find the best cells for your research in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.ImmunologyImmunological techniques measure and characterize immune responses. Immunology kits and analysis systems often use techniques such as ELISA, radioimmunoassay (RIA) and immunodiffusion assays, Immunohistochemistry, and flow cytometry. Immunologists use equipment such as flow Cytometers, plate readers, plate washers and fluorescent microscopes.Cell-Based AssaysCell-based assays are used to monitor the presence, quantity and activities of a desired cellular analyte including drug molecules or biomarkers. This can reveal information on cell health (apoptosis, cytotoxicity, viability and proliferation assays), cell metabolism, cell migration and cell signaling mechanisms. Find the best cell-based assay products, kits and equipment with our peer reviewed product directory: compare products, check customer reviews and receiving pricing direct from manufacturers.Vaccine DevelopmentVaccine development focuses on creating immunizations to protect against infectious diseases. The process involves identifying antigens, developing and testing vaccine efficacy, and ensuring safety through preclinical testing and multiple clinical trial phases. Scientists use various approaches, including weakened or inactivated viruses, protein subunits, or mRNA. Advanced platforms and rapid diagnostic tools aid in vaccine research and testing. Explore vaccine development solutions in our peer-reviewed product directory; compare products, read reviews, and get pricing directly from manufacturers. Cell CultureCell culture involves growing cells under controlled conditions, typically outside of their natural environment, to study cellular behavior, drug response, and disease models. Cell culture is crucial in biotechnology and biomedical research. Explore cell culture products in our peer-reviewed product directory; compare products, check reviews, and get pricing directly from manufacturers.Cancer ResearchAlthough cancer is often referred to as a single condition, it actually consists of more than 100 different diseases. Microscopy, mass spectrometry, high throughput sequencing and flow cytometry are some of the most common techniques employed in cancer research labs.

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Irvine Scientific Introduces Chemically-Defined Dendritic Cell Culture Medium for Immunotherapy Applications