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Invitrogen Features New Scientific Online Resources at American Society for Cell Biology (ASCB) Meeting

Invitrogen Limited
11 Dec 2006

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Invitrogen Corporation, a leader in life science research, today introduced the newest member of its free online scientific resource collection, iGene, a platform that allows researchers to conveniently search for experimental reagents by gene or protein.

This announcement, as well as the launch of the Premo™ cameleon calcium sensor, which uses fluorescent protein color emission to detect calcium levels in live cells for cell signaling studies, was made during the American Society for Cell Biology (ASCB) 2006 Annual Meeting this week.

Invitrogen developed its suite of online bioinformatics solutions - including the iProtocol™ Online Library, the iPath™ Online Bioatlas, and the iGene gene or protein search engine resource - to simplify the transition from experimental planning to selecting optimal research products. By integrating all known human, mouse, and rat genes and proteins into one database, the iGene search engine helps scientists quickly filter through more than 250,000 products related to their gene or protein of interest. Researchers can search using several criteria, including keyword, gene accession number, gene symbol, or batch search to find all of the antibody, assay, protein, cloning, qPCR, or RNAi products available for their specific experimental needs. Search results also link to external resources at the National Center for Biotechnology Information (NCBI) and to relevant signaling and metabolic pathway maps on the iPath™ Online Bioatlas. To explore this resource, visit the article webpage.

"As the leading provider of integrated research solutions, Invitrogen's goal is to drive standardization of technologies and methods by making available to scientists worldwide a series of top-quality, application-based bioinformatics tools completely free of charge," said Michael Stapleton, Vice President of Marketing/eBusiness at Invitrogen. "Invitrogen's rapidly expanding online scientific efforts are at the forefront of the internet revolution, taking advantage of the most effective medium for promoting best practices in research."

Invitrogen also announced the launch of its Premo™ cameleon calcium sensor, which will provide advantages in imaging applications as well as in compound screening employing HTS methodologies. Premo™ cameleon is a genetically encoded fluorescent protein-based sensor for cellular calcium signal measurements. It provides a ratiometric read-out at visual excitation wavelengths in the presence of calcium and interferes minimally with cell physiology. Conveniently pre-packaged in the biosafe and nontoxic BacMam insect virus delivery format, Premo™ cameleon is designed for live-cell application to a broad range of mammalian cells, including neuronal, primary, and stem cells.

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AntibodiesAntibodies are used in techniques such as confocal and fluorescence microscopy, flow cytometry, ELISA, ELISPOT, immunohistochemistry, western blotting and immunopreciptation. Select specific antigen reactivity, high specific affinity, low non-specific binding, monoclonal or polyclonal, primary or secondary antibodies and associated conjugates such as an enzyme or dye for visualization.Genome AnalysisGenomics, the study of genomes, includes functional genomics, evolutionary genomics and comparative genomics. There are many genomic technologies such as DNA sequencing of whole genomes, computational biology and bioinformatics. DNA and nucleic acids must be isolated and concentrated from cells for analysis with kits, automated analyzers and software. Other useful technologies for studying genomics include PCR, microarrays and electrophoresis.ProteomicsProteomics is the systemic bioinformatics study of proteins and amino acids, including their structure, size, function and identification. Tools used in proteomics include chromatography, blotting and gels, protein arrays, mass spectrometry and ELISA and associated analysis software. Analyzers and proteomic systems should be sensitive, high resolution, fast and may be automated for high-throughput.High-Throughput ScreeningHigh-throughput screening (HTS) is an automated drug discovery technique for identification of active compounds against a compound library. Use HTS readers and integrated assay preparation / analysis workstations to screen your compounds. Identify active compounds against various HTS libraries, including membranes, proteins and peptides and HTS cell lines. Find the best high-throughput screening products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.PCR and Thermal CyclingPolymerase chain reaction (PCR) kits and thermal cyclers are used for the in vitro amplification of DNA permitting subsequent analysis and experimental procedures. Explore a range of high-quality polymerase, primers and nucleotides or simplify your workflow with a PCR mastermix. Find reverse transcription PCR (RT-PCR) and cDNA synthesis kits for RNA products and libraries. Quantitatively measure the amplification of DNA with real-time PCR (qPCR) and droplet digital PCR (ddPCR) kits and systems, and discover automated PCR setup solutions to increase throughput. Alternative DNA amplification methods also include recombinase polymerase amplification (RPA) kits. Find the best PCR kits and thermal cyclers and purification equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Gel Doc / Image AnalysisGel documentation (gel doc) or gel imaging systems are used for the analysis of proteins, antibodies and nucleic acid immobilized in polyacrylamide or agarose gels, membranes or microarrays. Explore a range of a gel imaging systems, densitometers, scanners, transilluminators or UV lamp + CCD cameras for your image analysis solutions. Colorimetric, fluorescent and/or radioisotopic samples can be visualized and documented for further analysis. See gel doc / Image analysis software for quantitative 1D and 2D analysis of your samples. Find the best gel doc / image analysis products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Chem / BioinformaticsCheminformatics and bioinformatics are computational techniques used in chemistry and biology, respectively, for data acquisition, processing and storage. Cheminformatics focuses on compound information, whereas bioinformatics is mainly applied to analysis and modeling of genomics, genetic and sequencing information. Hardware and software is available for data acquisition, analysis, management and storage.Cell-Based AssaysCell-based assays are used to monitor the presence, quantity and activities of a desired cellular analyte including drug molecules or biomarkers. This can reveal information on cell health (apoptosis, cytotoxicity, viability and proliferation assays), cell metabolism, cell migration and cell signaling mechanisms. Find the best cell-based assay products, kits and equipment with our peer reviewed product directory: compare products, check customer reviews and receiving pricing direct from manufacturers.RNA InterferenceRNA interference (RNAi) uses siRNA or miRNA for transcriptional silencing, gene knockdown and regulation of gene expression. RNAi requires chemical synthesis, introduction of DNA vectors into cells, an assay of RNAi effects and RNAi quantification or analysis. Consider target sequence selection, reagent preparation, controls, high specificity and effectiveness and low non-specific gene knockdown.

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