Invetech Expands its Service Offering into the Drug Discovery Market

23 Sept 2007

Product news

Invetech, a worldwide leader in the development of biomedical instruments and automated research & manufacturing processes, has extended its innovative service offering to the drug discovery market. The company's expertise crosses a number of disciplines crucial to the drug discovery process including liquid handling, plate handling, robotics, software interfaces, optics, specialized detection systems, miniaturization and integration.

Identifying the best commercial direction for clients is Invetech’s principal goal. Taking a holistic approach from concept through to market, the company works collaboratively with its clients to deliver an integrated range of instrument development, custom automation and systems integration services. Engineering is tightly coupled with in-house application science to enable field representative product testing during the development process. In-house bio-safe laboratories are available for testing of early prototypes with real samples in a representative environment, and for subsequently supporting replicated systems at client sites globally.

Jari Palander, Vice President of North American Operations at Invetech, comments: “Invetech is capable of handling difficult challenges - our scale, breath of expertise and skills, and diverse project experience enables us to think out-of-the-box and uncover innovative, proprietary solutions and integrate these with our clients’ new and existing systems.”

Invetech’s track record builds on thousands of development projects worldwide. The company has recently demonstrated its expertise with the development of the base technology with complex multi-lane microfluidics on a silicon based fluidics chip. In a matter of months, Invetech designed a proprietary drug discovery platform on that base technology, integrating commercial autosamplers with complex fluidics and high performance fluorescence cellular imaging. The final system enabled previously unfeasible cellular assays for cell apoptosis and ADME/Tox analysis. In another case, Invetech was asked to develop an in-house high throughput screening platform on behalf of a leading North American company. Working in close collaboration with the client’s technology R&D department enabled Invetech to enhance the design of the system and replicate it for supply to global divisions.

Links

Tags

Lab-on-a-ChipLab-on-a-chip (LOC) technology uses microfluidic chips, such as microarrays, to perform biochemical assays on a small scale. Benefits of lab-on-a-chip include the small volume of sample required as well as the speed of analysis. In selecting lab-on-a-chip devices consider the assay, cost, reliability, sensitivity and signal to noise ratio.High-Throughput ScreeningHigh-throughput screening (HTS) is an automated drug discovery technique for identification of active compounds against a compound library. Use HTS readers and integrated assay preparation / analysis workstations to screen your compounds. Identify active compounds against various HTS libraries, including membranes, proteins and peptides and HTS cell lines. Find the best high-throughput screening products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Gel Doc / Image AnalysisGel documentation (gel doc) or gel imaging systems are used for the analysis of proteins, antibodies and nucleic acid immobilized in polyacrylamide or agarose gels, membranes or microarrays. Explore a range of a gel imaging systems, densitometers, scanners, transilluminators or UV lamp + CCD cameras for your image analysis solutions. Colorimetric, fluorescent and/or radioisotopic samples can be visualized and documented for further analysis. See gel doc / Image analysis software for quantitative 1D and 2D analysis of your samples. Find the best gel doc / image analysis products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Microplate Readers / DetectorsMicroplate readers are used to automate the detection and analysis of labeled or label-free components in microplates during assays or live-cell monitoring. Microplate readers are generally distinguished by their mode of detection. Types include absorbance, luminescence, fluorescence intensity, fluorescence polarization, TRF / FRET and multimode microplate readers. Microplate readers deliver a high throughput of samples by reading multiple wells simultaneously, with the 96-well format the most commonly used. As a result, microplate readers are often used in the drug discovery, bioassays, research and pharmaceutical industries for screening applications. Microplate loading can also be automated, with robotic microplate stackers to increase throughput. Find the best microplate readers in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Integration ServicesIncorporate lab systems, software and equipment with integration services.ADME-ToxicologyADME-toxicology (ADME-Tox) studies are used in pharmacology and pharmacokinetics to assess the activity/toxicity of drugs <i>in vivo</i> or <i>in vitro</i>. Find bioassays for absorption, distribution, metabolism, and excretion of drug molecules including cytotoxicity, transporter/permeability, metabolism and activity assays as well as hepatocytes and cell lines for ADME. Find the best ADME-toxicology products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Cell-Based AssaysCell-based assays are used to monitor the presence, quantity and activities of a desired cellular analyte including drug molecules or biomarkers. This can reveal information on cell health (apoptosis, cytotoxicity, viability and proliferation assays), cell metabolism, cell migration and cell signaling mechanisms. Find the best cell-based assay products, kits and equipment with our peer reviewed product directory: compare products, check customer reviews and receiving pricing direct from manufacturers.
Invetech Expands its Service Offering into the Drug Discovery Market