Innovative immune response investigation with Randox biochip

5 Oct 2008
Emily
Student / Graduate

Product news

Randox Laboratories have developed a revolutionary biochip array for the simultaneous quantitative testing of five cell adhesion molecules (CAMs). CAMs are complex membrane proteins that play a key role in immune processes and are elevated in certain disease states associated with atherosclerosis including stroke and cardiovascular disease.

The Randox adhesion molecules array includes intercellular and vascular cell adhesion molecules (ICAM-1 and VCAM-1) as well as the selectins (E, P and L). During an immune response, selectins initiate the interaction between leukocytes and endothelial cells, and then ICAM-1 and VCAM-1 mediate strong leukocyte-endothelial binding. These processes help leukocytes transmigrate into tissues and reach the site of infection.

The Randox adhesion molecules array allows simultaneous quantitative measurement of all five analytes with only 25µl of human plasma or serum. This revolutionary technology can promote understanding of the effect of these CAMs in pathological conditions and in turn lead to more accurate diagnosis and disease management.
The array based on ELISA principles can be run on the fully automated Evidence or the semi-automated Evidence Investigator.

Choose Randox innovative biochip array technology as a cost-effective and efficient solution for your research testing. This will place your laboratory at the forefront of scientific innovation.

Links

Tags

ELISAEnzyme-linked immunosorbent assays (ELISA), also known as enzyme immunoassays (EIA), are used for the detection and quantification of proteins, peptides and antibodies in a sample. ELISA often comes in kit format, with pre-selected antibody pairs to detect specific proteins or biomarkers of diseases such as diabetes and obesity, or cardiovascular and neurological disorders. Detection is made possible with chemiluminescent, fluorescent or colorimetric substrates and detection instruments such as microplate / ELISA readers. Other kits available include: Enzyme-linked immunospot (ELISPOT) assays for the quantification of protein-producing cells and chemiluminescent immunoassays (CLIA) kits. Find the best ELISA kits and products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Microplate Readers / DetectorsMicroplate readers are used to automate the detection and analysis of labeled or label-free components in microplates during assays or live-cell monitoring. Microplate readers are generally distinguished by their mode of detection. Types include absorbance, luminescence, fluorescence intensity, fluorescence polarization, TRF / FRET and multimode microplate readers. Microplate readers deliver a high throughput of samples by reading multiple wells simultaneously, with the 96-well format the most commonly used. As a result, microplate readers are often used in the drug discovery, bioassays, research and pharmaceutical industries for screening applications. Microplate loading can also be automated, with robotic microplate stackers to increase throughput. Find the best microplate readers in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.ImmunologyImmunological techniques measure and characterize immune responses. Immunology kits and analysis systems often use techniques such as ELISA, radioimmunoassay (RIA) and immunodiffusion assays, Immunohistochemistry, and flow cytometry. Immunologists use equipment such as flow Cytometers, plate readers, plate washers and fluorescent microscopes.
Innovative immune response investigation with Randox biochip