Innovation Academy: Good Science Equals Good Medicine

20 Aug 2014
Sonia Nicholas
Managing Editor and Clinical Lead

Editorial article

Innovative approaches in clinical diagnostics are at the heart of the drive to improve outcomes for patients in the key priority areas in healthcare. Sometimes new technology leads development; sometimes opportunities are created through a deeper scientific understanding of the underlying biology. In every case, better care should be the desired measure of success. This exclusive three-part series, based on material from the Viapath Innovation Academy, examines some specific examples of innovative practices that help to keep people healthy.

Download Part 1: Clinical utility of holotranscobalamin (holoTC, ‘Active’ B12) for the screening of vitamin B12 deficiency: application in a mixed patient population

While several methods exist for measuring vitamin B12 deficiency, these are beset by difficulties, including low sensitivity and specificity. Recent research has shown that the metabolically active portion of B12 (transcobalamin bound) – holotranscobalamin (holoTC) – offers a more reliable indication of B12 status.

Download Part 2: Impact of fecal calprotectin assay service on investigation of gastrointestinal symptoms

King’s College Hospital (KCH) was the first in the UK to study the measurement of fecal calprotectin as a valuable tool in the diagnostic pathway of GI tract diseases. It has now been proven to be a valuable biomarker, reducing the need for unpleasant colonoscopies.

Download Part 3: Introducing a complete biogenic amines service for the diagnosis / post-surgical monitoring of adult endocrine cancers

Innovative sample pre-treatment methodologies have been developed by the Clinical Biochemistry laboratory at King’s College Hospital (KCH) using novel, state-of-the-art analytical equipment to provide a faster, more reliable biogenic amines service to KCH patients and the wider NHS community.

Learn more about the biogenic amines service in this exclusive interview with Colin Stone, the Service Delivery Manager for Viapath’s (formally GSTS Pathology) Reference Biochemistry Laboratories based at King’s College Hospital, London, UK.

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HematologyIn Haematology / Hematology, complete blood cell counts (or full blood counts) are obtained using automated blood count analyzers to enumerate blood cell types.  Hematology also encompasses haemostasis and coagulation, thrombophilia and hemophilia, plasma viscosity and ESR analysis, hemoglobinopathies, cell morphology and haematinic measurement.ImmunologyImmunological techniques measure and characterize immune responses. Immunology kits and analysis systems often use techniques such as ELISA, radioimmunoassay (RIA) and immunodiffusion assays, Immunohistochemistry, and flow cytometry. Immunologists use equipment such as flow Cytometers, plate readers, plate washers and fluorescent microscopes.Clinical ChemistryBiochemistry (or clinical chemistry) involves the analysis of bodily fluids using chemical tests. Techniques used include HPLC, chromatography, spectroscopy, mass spectrometry, immunochemical, electrophoresis, turbidometric / spectrophotometric assay, MRI and ISE analysis. Tests are often carried out on plasma or serum but urine (urinalysis) and fecal specimens are also processed.Fecal CalprotectinBiogenic AminesVitamin B12
Innovation Academy: Good Science Equals Good Medicine