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Innova expands novel biomolecule conjugation technologies to simplify and accelerate research processes

Innova Biosciences Ltd.
29 May 2007

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Innova Biosciences Limited is delighted to announce the launch of an exciting new application using its Lightning-Link™ technology to provide a further addition to its revolutionary conjugation capabilities and product offering. Lightning-Link technology is used to join biomolecules forming ‘conjugates’, which are widely employed in bioscience, medical research as well as in diagnostic applications.

Innova has expanded its capabilities in a new application area, using Lightning-Link to speed up conjugation of the fluorescent protein phycoerythrin (PE) to disease-sensing monoclonal antibodies. Using a flow cytometer, a machine which is widely available in research and clinical laboratories worldwide, the resulting PE conjugates can be used to detect a variety of disease disorders. To address these needs Innova has launched its new Lightning-Link PE kit.

Announcing the launch, Innova’s Chief Executive Officer, Dr Nick Gee said, “We are very pleased to add the Lightning-Link PE kit to the growing range of Lightning-Link conjugation kits and other research products we offer. What is unique about Innova’s method of conjugating biomolecules is its speed and simplicity. The traditional conjugation techniques can take up to two hours, whereas the Lightning-Link approach takes less than 30 seconds, saving the user significant time and effort.”

One of the first scientists to utilize Innova’s new Lightning-Link PE kit in this application, Dr Andy Rawstron of Leeds Teaching Hospitals NHS Trust said, “This product has the potential to dramatically improve the ability of researchers to characterise new targets for diagnosis, monitoring and therapy of leukaemia and lymphoma.”

The Lightning-Link PE kit is a further new addition to Innova's existing range of Lightning-Link conjugation kits, which include Lightning-Link HRP (Horse Radish Peroxidase) and Lightning-Link AP (Alkaline Phosphatase). These kits complement other Innova offerings which include a range of phosphate detection reagents, affinity resins and assay kits as well as Innova’s conjugation services. Innova has a pipeline of additional exciting conjugation products which will be launched throughout 2007.

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AntibodiesAntibodies are used in techniques such as confocal and fluorescence microscopy, flow cytometry, ELISA, ELISPOT, immunohistochemistry, western blotting and immunopreciptation. Select specific antigen reactivity, high specific affinity, low non-specific binding, monoclonal or polyclonal, primary or secondary antibodies and associated conjugates such as an enzyme or dye for visualization.Flow Cytometry / Cell CountingFlow cytometers are used to count, sort and examine multiple characteristics of cells. Other cell analysis equipment includes image cytometers, cell counters, fluorescence-activated cell sorters (FACS), magnetic-activated cell sorters (MACS), and a range of flow cytometry assay kits. Flow cytometers can reveal information on cell viability, cell proliferation, apoptosis and cell cycle progression, as well as identify cell populations and intracellular or cell-surface molecules. Additionally, some flow cytometers, known as FACS, have an additional sorting function after analysis. Cell counters and image cytometers count live and dead cell populations and can also conduct cell proliferation assays. Find the best flow cytometers, cell counters and cell sorters in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Assay AssemblyAssay Assembly is technique used in drug discovery to develop assays to test the cytotoxicity, genotoxicity, or other activities of a compound on a cell. Assay assembly requires chip assembly, a delivery system and a detection and analysis method. Beneficial features of assay kits or automated systems include high-throughput, high speed and sensitivity and low signal to noise ratio.ImmunologyImmunological techniques measure and characterize immune responses. Immunology kits and analysis systems often use techniques such as ELISA, radioimmunoassay (RIA) and immunodiffusion assays, Immunohistochemistry, and flow cytometry. Immunologists use equipment such as flow Cytometers, plate readers, plate washers and fluorescent microscopes.Cell-Based AssaysCell-based assays are used to monitor the presence, quantity and activities of a desired cellular analyte including drug molecules or biomarkers. This can reveal information on cell health (apoptosis, cytotoxicity, viability and proliferation assays), cell metabolism, cell migration and cell signaling mechanisms. Find the best cell-based assay products, kits and equipment with our peer reviewed product directory: compare products, check customer reviews and receiving pricing direct from manufacturers.Protein PurificationProtein purification is a vital step in drug discovery, therapeutics, biotech and life science research. The purification process typically involves subcellular or membrane protein extraction with cell lysis kits, separation of proteins from cell debris by filtration or spin columns, and the isolation of proteins of interest from other proteins and impurities with affinity purification (including fusion protein tags and antibody binding proteins A, G and L), immunoprecipitation or chromatographic methods, such as ion exchange, size exclusion and immobilized metal affinity chromatography. All purification methods come in multiple formats for your laboratory needs, including agarose or magnetic beads, resins, columns and filter plates. Find the best protein purification equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.

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Innova expands novel biomolecule conjugation technologies to simplify and accelerate research processes