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IDT launches custom enrichment panels for faster and lower cost next-generation sequencing at ASHG 2019

Integrated DNA Technologies Inc.

Next-generation sequencing discovery pools enable larger custom panels and low sample numbers to speed up discovery

21 Oct 2019
Arran Tabary-Davies
Microbiologist

Product news

Integrated DNA Technologies, a leading genomics solutions provider, launches an affordable, rapid and flexible solution for targeted next-generation sequencing at the ASHG 2019 Annual Meeting, Houston, booth 520. NGS Discovery Pools are high quality, individually synthesized, 5’-biotinylated oligo pools designed to enable researchers to rapidly build custom panels at a fraction of the cost compared to conventional panels, making NGS accessible to more stages of research and speeding up projects.

Dr. Mirna Jarosz, Director of NGS Business Development at IDT, will be giving a presentation on the NGS Discovery Pools on Friday, October 18th at the ASHG. She commented, “At IDT, we understand that for scientists the difference between waiting days versus weeks for high quality reagents can mean everything. In our continued mission to exceed the needs of researchers, we are pleased to launch NGS Discovery Pools. These probes leverage the same high quality platform as our popular and trusted xGen Lockdown Probes and arrive in a matter of days for a fraction of the cost. This will enable our customers to use our high-quality capture technology for smaller projects and in earlier stages where content may still be changing, allowing for a smooth transition to Lockdown Probes as projects are scaled up and validated for clinical use. With this launch, we’re pleased to now be able to offer solutions for the whole precision medicine journey, from discovery to diagnostics.”

IDT’s xGen Lockdown Probes are already the highest quality solution for target capture, trusted for clinical sequencing globally. The new NGS Discovery Pools offer the quality of individual synthesis at the speed and scale needed for discovery in precision medicine. NGS Discovery Pools enable rapid prototyping which can then be built out into high volume projects with Lockdown Probes.

Jarosz added, “We’re excited to bring NGS Discovery Pools to market as they are really going to open up NGS. They are an ideal tool for minimal residual disease testing in solid tumors, where small patient-specific panels delivered within days will enable the highest levels of sensitivity required for monitoring therapeutic response.”

IDT leverages its expertise in oligo manufacturing, combined with its proprietary production platform to permit high quality synthesis of custom capture probes - that are never subjected to the bias and errors that come with amplification. The custom NGS Discovery Pools work straight out of the box, thanks to the 30 years of quality control that has gone into building the best DNA synthesis platforms in the world.

IDT technical experts will be on hand at booth 520 at ASHG 2019 to provide more information on the new NGS Discovery Pools and answer any questions.

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Genome AnalysisGenomics, the study of genomes, includes functional genomics, evolutionary genomics and comparative genomics. There are many genomic technologies such as DNA sequencing of whole genomes, computational biology and bioinformatics. DNA and nucleic acids must be isolated and concentrated from cells for analysis with kits, automated analyzers and software. Other useful technologies for studying genomics include PCR, microarrays and electrophoresis.OligonucleotidesOligonucleotides are small nucleic acid polymers, usually less than 20 bases in length. Oligonucleotides can be made via enzymatic cleavage or more commonly by chemical synthesis with polymerases. Their use includes FISH, southern blots, microarrays and as primers in PCR. High fidelity synthesis kits and detection systems are available for easy production and detection, respectively.High-Throughput ScreeningHigh-throughput screening (HTS) is an automated drug discovery technique for identification of active compounds against a compound library. Use HTS readers and integrated assay preparation / analysis workstations to screen your compounds. Identify active compounds against various HTS libraries, including membranes, proteins and peptides and HTS cell lines. Find the best high-throughput screening products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Cellular PathologyCellular Pathology deals with the microscopic analysis of tissue samples and cells. Sample preparation and processing includes fixation, staining, sectioning and slide mounting, using equipment such microtomes and cryostats. In choosing immunohistochemistry and immunocytochemistry kits, consider chromogens, staining method, antibodies, microscopes and imaging.DNA SequencingDNA sequencing, such as sanger sequencing, is a biological technique that determines the precise order of nucleotide bases in a fragment or template of DNA. DNA sequencers and genetic analyzers are based on capillary electrophoresis, where labeled DNA fragments are electrophoretically separated by size as they migrate through a polymer. Find the best DNA sequencing products, including DNA sequencing kits, genomic libraries and genetic identity kits in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Biopharmaceutical AdvancesBiopharmaceutical advances follow the development of pharmaceuticals derived from biotechnology, also known as biotechnology medicines. Biopharmaceuticals may be produced from cell lines, plants, or microbial cells. Important considerations of biopharmaceutical use include application, cost, production process and purification.Next Generation SequencingNext-generation sequencing (NGS), also known as whole-genome sequencing, high-throughput sequencing and massive parallel sequencing, produces and analyses thousands to millions of nucleotide sequences at once. Sequencing systems operate via varying technologies depending on the manufacturer, including sequencing by synthesis, ligation, pyrosequencing, ion semiconductor and single-molecule real-time sequencing. For NGS, library preparation is paramount to successful sequencing. In this section, explore a range of library preparation kits, from targeted, amplicon-based or hybridization-based kits including epigenomic, transcriptomic and genomic workflows to fragmentation kits. Find the best next-generation sequencing products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.SequencingSequencing refers to determining the order of nucleotides in a DNA or RNA molecule. This process is essential in genomics, diagnostics, and evolutionary biology. Techniques like next-generation sequencing (NGS) and Sanger sequencing provide high-throughput and precise data for analyzing genomes and transcriptomes. Browse our peer-reviewed product directory to find the best sequencing tools and reagents, compare products, check reviews, and get pricing directly from manufacturers.Genome SequencingGenome sequencing involves determining the complete DNA sequence of an organism's genome. It provides crucial information about genetic variations, mutations, and diseases. Advances in sequencing technologies, such as next-generation sequencing (NGS), have accelerated research in genomics, diagnostics, and personalized medicine. Explore genome sequencing tools in our peer-reviewed product directory; compare products, check reviews, and get pricing directly from manufacturers.

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IDT launches custom enrichment panels for faster and lower cost next-generation sequencing at ASHG 2019