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HPLC & Automated Tablet Dissolution Testing Come Together

Gilson, Inc.
12 Jun 2012

Product news

The Gilson 241 Automated Double Dissolution System (ADDS) was developed with a Major Pharmaceutical company to address the growing need for increased dissolution testing by HPLC. The system controls the sampling and HPLC analysis of active drug components in dissolution media.

With the Gilson system, the dissolution media is circulated in a closed loop system by means of a Gilson Minipuls peristaltic pump and samples are taken at the specified time intervals through the use of an innovative flow-through HPLC vial.

The ADDS software controls the whole process from taking samples from the baths to injecting the samples onto ANY HPLC or UHPLC system. Samples can also be transferred into sealed HPLC vials for storage or processing at a later date.

There are 5 different pre-program methods. Sample lists can be imported from other software data packages or created by the user. Standards and samples can be run together in bracketed sample lists. Dedicated system suitability and cleaning protocols are available
The system is designed on Gilson’s tried and tested liquid handling platform and comes complete, with the Gilson 241 liquid handler, software, racks and sample pumps.

Gilson in the UK offers complete sales, support and service for all Gilson Pipetman® pipettes and liquid handling products in the UK and Ireland. Visit the company website for more information.

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UHPLC and HPLCHigh performance liquid chromatography (HPLC) and ultra high performance liquid chromatography (UHPLC), also known as UPLC, are analytical techniques used to separate, identify and quantitate components of complex mixtures including biological samples such as proteins and lipids as well as chemical mixtures of pesticides, drugs and oils. Both techniques are liquid chromatographic methods but differ by operating pressures (HPLC < 6000 psi < UHPLC ). Components of HPLC and UHPLC systems include columns, detectors, pumps, autosamplers and column heaters. Explore a range of UHPLC and HPLC columns for your specific sample needs including reverse phase, normal phase, ion exchange, HILIC, ion exclusion and size exclusion columns. For more specialized HPLC, explore FPLC, countercurrent LC and simulated moving bed systems. Find the best UHPLC and HPLC equipment in our peer reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Pipettes and DispensersPipettes and dispensers are essential lab equipment used to dispense measured volumes of liquid accurately. Explore a range of manual and electronic pipettes, including single and multichannel, serological and volumetric pipettes, as well as a range of pipette tips. Bottle-top dispensers are also available for simple and fast solvent dispensing. Find the best pipettes & dispensers in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Automated Liquid HandlingAutomated liquid handling equipment is used to mix, dilute and dispense allotted volumes of liquid into microplates and other vessels automatically. The robotic, liquid handling arms can dispense from single channel to 3456 multichannel as well as operate nanoliter dispensing, enabling high throughput of samples. Find the best automated liquid handlers in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.HPLC Method DevelopmentIt is important to develop and validate HPLC methods in order to identify, quantify or purify compounds of interest in the most efficient way. Effective method development ensures optimization, quality control and cost effectiveness.Liquid Handling WorkstationLiquid handling workstations automate the process of sample preparation, improving accuracy and efficiency. These systems are essential for high-throughput applications in biological, chemical, and pharmaceutical research, reducing human error and increasing reproducibility. Workstations come equipped with robotic arms, pipetting tools, and other accessories to streamline lab workflows. Explore liquid handling workstations in our peer-reviewed product directory; compare products, check reviews, and get pricing directly from manufacturers.

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HPLC & Automated Tablet Dissolution Testing Come Together