How to generate mass data quickly and unleash greater productivity in your biopharma lab

Download this free eBook today to streamline development and accelerate time-to-market

23 Jul 2020
Georgina Wynne Hughes
Editorial Assistant

Editorial article

As the biopharmaceutical industry continues to grow and expand into new and ever more complex modalities, biopharmaceutical developers and manufacturers are in urgent need of analytical solutions that can streamline development, accelerate time-to-market and enable greater productivity.

Mass spectrometry (MS) is arguably the most important analytical tool in the biopharma developer’s tool chest but its historic size, cost and complexity have limited its use. To address this industry dynamic, Waters has been working to make mass spectrometry instruments smaller, easier to use and more accessible to analytical scientists throughout the organization.

This SelectScience application eBook is intended as a free resource for anyone in biopharmaceutical development, manufacturing and QC who wishes to make greater use of mass data, and who seeks to accelerate time-to-market and fuel greater productivity within their respective organizations.

Download this eBook today to find more about the biopharmaceutical applications of the ACQUITY QDa Mass Detector and the BioAccord system from Waters, including:

  • Increasing specificity and sensitivity in routine peptide analyses
  • LC-UV-MS-based synthetic peptide identification and impurity profiling
  • Improving glycan profiling in process development
  • Monitoring multiple attributes in a single assay
  • Enabling routine & reproducible intact mass analysis when data integrity matters
  • An integrated peptide attribute profiling and monitoring workflow for improved productivity
  • A platform method for the molecular mass analysis of the light & heavy chains of monoclonal antibodies
  • Increasing productivity and confidence for N-linked glycan analysis of biosimilars

Download the eBook today>>

BioAccord LC-MS System

Waters

The First SmartMS-Enabled Biopharma Solution  The Waters BioAccord System is an integrated system that simplifies high performance LC-MS biopharmaceutical analysis for every user. An easy-to-use system solution that puts the power to make decisions directly in your hands; a self-calibrating, self-optimizing, self-sufficient tool that equips you with high quality data you can use to tackle the challenges you face every day during biopharmaceutical development.

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ACQUITY QDa Mass Detector

Waters

The ACQUITY QDa® Mass Detector gives you certainty above all else. You can minimize the risk of unexpected coelutions or components and confirms trace components with the analytical confidence of mass detection. The ACQUITY QDa® Detector is a mass detector built around the needs of analytical scientists for chromatographic analysis. Robust, reliable and requiring no sample adjustments, it just integrates with your current LC, ACQUITY UPLC, ACQUITY UPC2 and purification systems. You'll enhance the analytical value and productivity of each analysis, and you won't need to run all the additional assays or time-consuming alternative techniques or even wait for results from specialist labs that cost your laboratory productivity. With the ACQUITY QDa® Detector, you now have information-rich mass spectral data to complement data from your current Waters® optical detectors, including the ACQUITY UPLC PDA, TUV, ELS, and FLR detectors, as well as the ACQUITY UPC² PDA Detector. This mass spectral information integrates seamlessly into the same workflow; routinely giving you more complete separation characterization. Features: Intuitive operation More information from every sample Effortless integration Increased efficiency Resolving complexity Applications: Food & Environment Life Sciences and Pharmaceuticals Chemical

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Mass SpectrometryMass spectrometry (MS) is a powerful analytical technique used to identify and quantify molecules based on the mass-to-charge ratio of gas-phase ions. It provides detailed information about the structure, composition, and properties of compounds and is widely used across fields such as environmental monitoring, materials science, drug discovery and development, food and beverage testing, and wider chemical research. Key MS techniques include tandem mass spectrometry (MS/MS), liquid chromatography–mass spectrometry (LS-MS) and inductively coupled plasma (ICP-MS). Choosing from these wide range of techniques and technologies can be a daunting task, so keep up to date with scientific applications, performance expectations, and customer reviews here all in one place. Visit our product directory to receive quotes direct from the manufacturer. Biopharmaceutical AdvancesBiopharmaceutical advances follow the development of pharmaceuticals derived from biotechnology, also known as biotechnology medicines. Biopharmaceuticals may be produced from cell lines, plants, or microbial cells. Important considerations of biopharmaceutical use include application, cost, production process and purification.BiopharmaceuticalsBiopharmaceuticals are proteins and other compounds (such as nucleic acids) produced by living organisms that have uses as therapeutics or for in vivo diagnostics. The most well known example of a biopharmaceutical product, and the first to be approved for therapeutic use, was recombinant human insulin.PharmaceuticalsPharmaceuticals are medicinal drugs used in healthcare to diagnose, prevent, cure and treat illnesses. Pharmaceuticals that are excreted after use appear in wastewater and can have detrimental effects on the environment.
How to generate mass data quickly and unleash greater productivity in your biopharma lab