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Hot melt extrusion: A holistic insight for process optimization

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Join this webinar to hear more about hot melt extrusion (HME) and how it can be utilized to develop versatile dosage forms

12 Mar 2020
Sophie Ball
Publishing / Media

Expert insights

Hot-melt extrusion (HME) is gaining attention in the pharmaceutical industry due to its high manufacturing efficiency, economic benefits, and ability to develop versatile dosage forms. In this upcoming webinar, hear from Dr. Rui Chen, Global Application Manager, Spectroscopy, Thermo Fisher Scientific, to learn more about HME and process optimization using near-infrared spectroscopy, Raman microscopy, and scanning electron microscopy (SEM).

Watch this webinar to hear how HME can be utilized to develop versatile dosage forms, especially for poorly soluble active pharmaceutical ingredients (API). Chen will discuss a case study on acetaminophen (APAP) in hydroxypropyl methylcellulose (HPMC) matrices prepared by HME, using an integrated analytical approach involving Fourier transform near-infrared spectroscopy (FT-NIR), SEM and Raman microscopy. Data from different analytical techniques are correlated and reconciled to elucidate the impact of process parameters, such as temperature and screw speed, on the formation of solid dispersions. Chen also discusses in-line process stability monitoring using FT-NIR.

Register Now

Watch this webinar to learn:

  • Why FT-NIR and MVA (multivariate analysis) is a superb PAT (process analytical technology) technique for HME process optimization and monitoring to ensure product consistency
  • How THz Raman imaging can shed light on HME process optimization
  • How an integrated analytical approach can enhance the understanding of HME for better formulation and process optimization

Who should attend:

  • Drug formulation scientists, drug development scientists, and PAT engineers in pharma, CMOs and CDMOs
  • Analytical chemists supporting drug development
  • Laboratory managers/directors/supervisors
  • Quality control and assurance labs
  • Industry regulators

The live webinar and Q&A session will take place on Monday, March 23, at:

  • 16:00 GMT
  • 12:00 EDT
  • 09:00 PDT
  • 17:00 CET

Register to watch the full webinar here>>

SelectScience runs 3-4 webinars a month across various scientific topics, discover more of our upcoming webinars>>

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Raman SpectroscopyRaman spectroscopy is used to discern the vibrational and rotational states of molecules and hence the chemical composition of a sample by measuring the inelastic scattering of monochromatic light. Explore a range of Raman spectrometers, including handheld/portable Raman spectrometers for QC/QA labs and in situ spectrometers for processes. Conduct Raman imaging for microanalysis of mixed samples using a Raman microscope. Raman spectrographs are also available. Find the best Raman spectroscopy products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Thermal Analysis EquipmentThermal analysis equipment is used for measuring heat flow, weight loss, dimension changes or thermomechanical properties and is important for analyzing a material’s performance and stability. Thermal analysis equipment includes differential scanning calorimeters (DSC), thermogravimetric analyzers (TGA), thermomechanical analyzers (TMA), dilatometers, thermometers, vapor sorption analyzers, boiling and melting point apparatus. Thermal analyzers can reveal properties such as melting, crystallization and glass transitions or other processes such as oxidation, decomposition, volatilization, as well as coefficients of thermal expansion and modulus. Find the best thermal analysis equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Electron MicroscopyElectron microscopes (EM) are used to create high-resolution images of samples at the nanoscale by means of an accelerated beam of electrons as a source of illumination. Types of electron microscope include scanning electron microscopes (SEM), transmission electron microscopes (TEM), scanning transmission electron microscopes (STEM) and cryo-electron microscopes. Focused ion beam (FIB) microscopes are useful for modifying or milling a sample surface with nanometer precision, as well as imaging. Find the best electron microscopes in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.NIRSelectron microscopy

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Hot melt extrusion: A holistic insight for process optimization