Horizon Discovery and Desktop Genetics Collaborate on CRISPR Design Platform

17 Dec 2013
Sarah Thomas
Associate Editor

Product news

Horizon Discovery (Horizon), a leading provider of research tools to support translational genomics and the development of personalized medicines, today announced it has entered into a collaboration agreement with Desktop Genetics for development of a CRISPR design platform. The platform will be used by Horizon to quickly identify the best guide-RNAs in the human genome for each gene editing task, as part of its GENESIS™ suite of gene editing technologies.

Desktop Genetics will design and implement algorithms for the new platform based on Horizon's input and CRISPR knowledge. Horizon licensed the CRISPR gene editing technology from Harvard University in September 2013, adding to its existing rAAV and ZFN gene editing capabilities. Through its GENESIS™ precision gene-editing platform, Horizon offers researchers an unrivalled toolbox capable of performing rapid functional genomics experiments, as well as creation of high-precision human disease models for deployment at all stages of drug discovery and diagnostic development.

“Horizon is placing significant investment in ensuring our scientists and customers have access to the best gene editing technology, or combination of technologies, to most effectively achieve their goals,” commented Eric Rhodes, CTO, Horizon Discovery. “We are committed to ensuring that we continue to be able to offer our customers a best-in-class solution for their research needs.”

Riley Doyle, CEO of Desktop Genetics, said: “Desktop Genetics develops novel software tools that are optimized for applications in gene expression, antibody engineering, cell line development, functional genomics, gene-editing and protein production. We are excited to be working with Horizon, a leader in its field, on its application of the cutting-edge CRISPR technology, and on expanding our offerings in the growing fields of genome and cell line engineering.”

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Genome AnalysisGenomics, the study of genomes, includes functional genomics, evolutionary genomics and comparative genomics. There are many genomic technologies such as DNA sequencing of whole genomes, computational biology and bioinformatics. DNA and nucleic acids must be isolated and concentrated from cells for analysis with kits, automated analyzers and software. Other useful technologies for studying genomics include PCR, microarrays and electrophoresis.Chem / BioinformaticsCheminformatics and bioinformatics are computational techniques used in chemistry and biology, respectively, for data acquisition, processing and storage. Cheminformatics focuses on compound information, whereas bioinformatics is mainly applied to analysis and modeling of genomics, genetic and sequencing information. Hardware and software is available for data acquisition, analysis, management and storage.Gene Expression and Molecular CloningMolecular cloning is a set of techniques that utilizes vectors to transfer recombinant DNA into host cells and is an essential tool for investigating the expression of genes and proteins in bacterial or mammalian cells. A variety of vectors optimized for gene cloning and expression in a range of host organisms are available, alongside competent cells for genetic replication. Here, you can explore a range of molecular tools, high-quality genomic and cDNA libraries, premade clones, transformation and transfection reagents and mutagenesis or gene expression detection assays and expression arrays. Find the best gene expression and molecular cloning products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Genome EditingGenome editing involves altering the DNA of an organism, which holds promise for disease treatment, agriculture, and gene therapy. Techniques like CRISPR-Cas9 are revolutionizing this field, enabling precise genetic modifications. Explore genome editing tools in our peer-reviewed product directory; compare products, check reviews, and get pricing directly from manufacturers.
Horizon Discovery and Desktop Genetics Collaborate on CRISPR Design Platform