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Horizon and UK NEQAS Partner to Improve Accuracy of Lung Cancer Diagnostics

2 Feb 2012
Sonia Nicholas
Managing Editor and Clinical Lead

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The UK based company Horizon Diagnostics, a division of Horizon Discovery, has announced the signing of a strategic partnership agreement with UK NEQAS. The partnership will focus on the development of genetically defined reference standards for novel lung cancer biomarkers, to help guide personalized medicine.

The reference materials will be used to minimize variability involved in fluorescence in situ hybridization (FISH) and immunohistochemistry (IHC). HorizonDx is the first company to offer human genomic reference standards containing defined allelic ratio’s offering an unprecedented level of control to the diagnostics industry.

Under the terms of the agreement, UK NEQAS ICC (the UK National External Quality Assessment Service) will receive an exclusive license to distribute reference standards related to certain lung cancer biomarkers in the UK and Europe, for the sole purpose of proficiency testing within its quality assessment programme.

The partnership announcement follows the launch of HorizonDx’s launch of a suite of genetically-defined fixed formalin, paraffin embedded (FFPE) cell line standards in September 2011. These cell lines contain defined stoichiometric ratios of, among others, the seven variants of the K-Ras oncogene, for which testing is required to determine individual drug treatment regimens for colorectal cancer patients.

Dr Paul Morrill, Commercial Director, Horizon Discovery, commented: “Newly discovered mutations are rapidly shaping how and when novel cancer therapies are prescribed, and quality assurance for diagnostics is a key factor in the prescription of these therapies. Through this partnership with UK NEQAS, we look forward to seeing our genetically defined reference standards adopted in proficiency schemes and as batch controls, ultimately helping to improve the accuracy of diagnostic testing for patients.”

Keith Miller, Director of UK NEQAS ICC, commented: “Horizon’s application of its gene editing technology in development of reference standards is ideally suited to diagnostics proficiency testing. We look forward to working with them as the field of cancer therapeutics moves increasingly toward a more personalised approach.”

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Horizon and UK NEQAS Partner to Improve Accuracy of Lung Cancer Diagnostics