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HORIBA announces new Veloci BioPharma Analyzer for biopharma and pharma applications

HORIBA Scientific

Advanced molecular fingerprinting offers precision and efficiency

14 Mar 2025

Product news

HORIBA has launched Veloci™, a biopharma analyzer with A-TEEM™ Technology (simultaneous Absorbance, Transmittance, and Fluorescence Excitation-Emission-Matrix (EEM)), providing advanced molecular fingerprinting for life science applications.

The BioPharma Analyzer is a unique A-TEEM™ spectroscopy solution for the biopharma and pharma industries that combines the selectivity of chromatography with the advantages of optical spectroscopy. This technology provides a fast, cost-effective, and user-friendly approach to component analysis and eliminates the need for traditional column-based separations.

The Veloci BioPharma Analyzer utilizes label-free intrinsic fluorescence analysis, providing unprecedented precision and efficiency over a wide range of applications, including monoclonal antibody discrimination, cell media monitoring, vaccine characterization, protein stability analysis, and adeno-associated virus (AAV) quantification.

The Analyzer combines the selectivity of chromatography with the speed and simplicity of spectroscopy providing superior sensitivity versus traditional methods such as high performance liquid chromatography (HPLC)/mass spectrometry (MS) and Raman spectroscopy. It requires no sample preparation or solvent use, and it accelerates workflows, with analysis times as short as three minutes per sample for the hundreds of EEM spectra acquired and processed, compared to 30 minutes for traditional methods like ultra performance liquid chromatography (UPLC), hereby reducing both time and environmental impact.

The Veloci ™A-TEEM™ BioPharma Analyzer can:

• when analyzing antibody drug conjugates, distinguish between the monoclonal antibodies (mAbs) portion of the drug, the payload, and the linker with over 90% sequence homology, delivering rapid and accurate intrinsic fluorescence analysis in their natural state.

• Measure capsid empty/full ratios and differentiate AAV subtypes in a label-free manner, bypassing the need for analytical centrifuges.

• Monitor cell culture media quality for bioreactors.

• Provide vaccine characterization by identifying formulations, detecting aggregation, and monitoring batch-to-batch variations.

• Offer protein stability by detecting early signs of aggregation, safeguarding against reduced potency and increased side effects.

• Discriminate between exosome subtypes, enabling advanced studies on extracellular signaling and therapeutic applications.

Cary Davies, global product line manager for fluorescence products at HORIBA, said, “The Veloci™ Biopharma Analyzer is a significant advancement of our core A-TEEM™ spectroscopy product line by offering our industrial partners easy workflows and multivariate analysis, a new open platform communications (OPC) unified architecture (UA) process analytical technology (PAT) interface and full compliance solutions.”

Andrew Whitley, Vice President and Field Officer for the HORIBA Life Science Business Field said, “The pharmaceutical industry is increasingly using fluorescence spectroscopy, and more specifically, ATEEM™ for QA/QC and as a process analytical technology (PAT) for manufacturing control. A-TEEM™ provides similar information to mass spectrometry and chromatography, but faster and easier, typically no consumables, while like any optical technique is easily implemented. Andrew continued, “Veloci’s ATEEM™ Technology offers the speed, cost-effectiveness and solutions required across research, PAT and QA/QC.

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Mass SpectrometryMass spectrometry (MS) is a powerful analytical technique used to identify and quantify molecules based on the mass-to-charge ratio of gas-phase ions. It provides detailed information about the structure, composition, and properties of compounds and is widely used across fields such as environmental monitoring, materials science, drug discovery and development, food and beverage testing, and wider chemical research. Key MS techniques include tandem mass spectrometry (MS/MS), liquid chromatography–mass spectrometry (LS-MS) and inductively coupled plasma (ICP-MS). Choosing from these wide range of techniques and technologies can be a daunting task, so keep up to date with scientific applications, performance expectations, and customer reviews here all in one place. Visit our product directory to receive quotes direct from the manufacturer. UHPLC and HPLCHigh performance liquid chromatography (HPLC) and ultra high performance liquid chromatography (UHPLC), also known as UPLC, are analytical techniques used to separate, identify and quantitate components of complex mixtures including biological samples such as proteins and lipids as well as chemical mixtures of pesticides, drugs and oils. Both techniques are liquid chromatographic methods but differ by operating pressures (HPLC < 6000 psi < UHPLC ). Components of HPLC and UHPLC systems include columns, detectors, pumps, autosamplers and column heaters. Explore a range of UHPLC and HPLC columns for your specific sample needs including reverse phase, normal phase, ion exchange, HILIC, ion exclusion and size exclusion columns. For more specialized HPLC, explore FPLC, countercurrent LC and simulated moving bed systems. Find the best UHPLC and HPLC equipment in our peer reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Raman SpectroscopyRaman spectroscopy is used to discern the vibrational and rotational states of molecules and hence the chemical composition of a sample by measuring the inelastic scattering of monochromatic light. Explore a range of Raman spectrometers, including handheld/portable Raman spectrometers for QC/QA labs and in situ spectrometers for processes. Conduct Raman imaging for microanalysis of mixed samples using a Raman microscope. Raman spectrographs are also available. Find the best Raman spectroscopy products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.ProteomicsProteomics refers to the analysis of proteins through a variety of different experiments in order to understand structure and functionality. Typical techniques include protein purification and mass spectrometry. Monoclonal AntibodiesMonoclonal antibodies (mAbs) are lab-made molecules that can bind to specific antigens on cells, making them highly effective in treating cancers, autoimmune diseases, and infections. These targeted therapies are transforming the treatment landscape for many conditions. Browse our peer-reviewed product directory to find monoclonal antibodies for research and clinical applications; compare products, check reviews, and get pricing directly from manufacturers.aavVaccine DevelopmentVaccine development focuses on creating immunizations to protect against infectious diseases. The process involves identifying antigens, developing and testing vaccine efficacy, and ensuring safety through preclinical testing and multiple clinical trial phases. Scientists use various approaches, including weakened or inactivated viruses, protein subunits, or mRNA. Advanced platforms and rapid diagnostic tools aid in vaccine research and testing. Explore vaccine development solutions in our peer-reviewed product directory; compare products, read reviews, and get pricing directly from manufacturers. Antibody Drug Conjugates

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HORIBA announces New Veloci BioPharma Analyzer for biopharma and pharma applications