High-Speed LC/MS Analysis with Three Times More Sample Capacity

15 Mar 2012
Roger Wayman
Administrator / Office Personnel

Product news

Shimadzu Scientific Instruments now offers the Nexera MP ultra-high performance liquid chromatography system with the SIL-30ACMP Autosampler. The SIL-30ACMP combines with the optional CTO-30AS column oven to create a premier front end for all LC/MS systems. The new autosampler allows users to configure a complete high-speed LCMS system capable of analyzing multiple samples accurately, quickly and with low carryover, making Nexera the ultimate front-end system for LC/MS.

Building on the proven Shimadzu design, the SIL-30ACMP provides low carryover of 0.0015% or less, minimizing sample contamination. It provides reproducibility of 1 percent or less in
0.5 μL injections and of 0.2 percent or less in injections of 5 μL or more. The autosampler also offers the world’s fastest cycle time at 14 seconds.

The SIL-30ACMP holds up to six plates for increased capacity. Using 384 well plates, the SIL-30ACMP can perform continuous analysis on 2,304 samples — the highest number of samples that can be analyzed in a closed-type, safe-design autosampler. It can also continuously analyze 324 samples using 1.5 mL vials. Additionally, three different plate types can be set in the sample racks simultaneously, adding to its versatility. The system also houses a standard/control sample rack holding 1.5 mL vials, which is useful while testing multiple unknown samples with microtiter plates. With its open-access design, the SIL-30ACMP permits users to access the sample racks at any time, except during the injection process.

The optional CTO-30AS mounts directly on the side for close proximity to the autosampler and can be positioned from the vertical to the horizontal to minimize tubing lengths. This reduces extra column band broadening effects, especially important for UHPLC applications.

Links

Tags

AutosamplersAutosamplers are automated sample loaders used with a number of separation and analytical techniques. HPLC autosamplers use automated partial or full-loop injection systems and place samples in vials or microplates for analysis. Autosamplers can also be used for elemental analysis. Features to consider include repeatability, syringe capacity, footprint and temperature controls.  UHPLC and HPLCHigh performance liquid chromatography (HPLC) and ultra high performance liquid chromatography (UHPLC), also known as UPLC, are analytical techniques used to separate, identify and quantitate components of complex mixtures including biological samples such as proteins and lipids as well as chemical mixtures of pesticides, drugs and oils. Both techniques are liquid chromatographic methods but differ by operating pressures (HPLC < 6000 psi < UHPLC ). Components of HPLC and UHPLC systems include columns, detectors, pumps, autosamplers and column heaters. Explore a range of UHPLC and HPLC columns for your specific sample needs including reverse phase, normal phase, ion exchange, HILIC, ion exclusion and size exclusion columns. For more specialized HPLC, explore FPLC, countercurrent LC and simulated moving bed systems. Find the best UHPLC and HPLC equipment in our peer reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.LC-MSLC-MS (liquid chromatography-mass spectrometry) systems and equipment are used for separation and quantitative analysis of complex mixtures, combining liquid chromatography and mass spectrometry. Quantify proteins, contaminants, pesticides or screen for drug metabolites with a high level of sensitivity. LC-MS systems and equipment include reverse phase, normal phase and specialized columns integrated with various MS detectors such as time-of-flight (TOF), quadrupole, orbitrap or ion trap mass analyzers. LC-MS/MS instruments equipped with a qTOF or triple quadrupole analyzer give greater sensitivity and resolving power to your analysis. Find the best LC-MS equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Mass SpectrometryMass spectrometry (MS) is a powerful analytical technique used to identify and quantify molecules based on the mass-to-charge ratio of gas-phase ions. It provides detailed information about the structure, composition, and properties of compounds and is widely used across fields such as environmental monitoring, materials science, drug discovery and development, food and beverage testing, and wider chemical research. Key MS techniques include tandem mass spectrometry (MS/MS), liquid chromatography–mass spectrometry (LS-MS) and inductively coupled plasma (ICP-MS). Choosing from these wide range of techniques and technologies can be a daunting task, so keep up to date with scientific applications, performance expectations, and customer reviews here all in one place. Visit our product directory to receive quotes direct from the manufacturer. PittconPittcon is one of the largest conferences and exhibitions dedicated to laboratory science. It brings together professionals and innovators in analytical chemistry, physics, and biology, offering a platform to explore the latest scientific tools and technologies. From cutting-edge laboratory instruments to emerging research trends, Pittcon is a must-attend event for professionals in research and development. High-Speed LC-MS
High-Speed LC/MS Analysis with Three Times More Sample Capacity