Guava Technologies Announces New Line of Antibody Reagents Optimized for Guava Systems

10 Mar 2006
Kerry Parker
CEO

Product news

Guava Technologies, Inc., a leading developer of cost-effective and accessible cell-analysis systems for life science research, drug discovery, development and clinical diagnostics, today announced the introduction of Express Cell Surface Antibodies, a new line of antibody reagents designed to identify subsets of hematopoetic-derived cells by their patterns of protein expression. This is the first of several new reagent lines that Guava intends to introduce this year for use by life sciences researchers.

Guava's new Express Cell Surface Antibody reagents allow researchers to examine a very specific population of hematopoetic-derived (blood) cell lines for their functional responses to compounds or other treatments. These antibodies have been conveniently optimized for ease of use with the Guava EasyCyte™ and EasyCyte Mini systems.

"With the introduction of Guava's new Express Cell Surface Antibodies, researchers will have the convenience of the first antibody reagents specifically pre-tested and pre-optimized for use with cytometry systems," said Lawrence Lem, Ph.D., Strategic Marketing & Reagent Product Manager. "These new reagents allow researchers to analyze the functional responses of one cell type in a mixed population of cells, such as whole blood. Importantly, our reagents are ideal for automated sampling in 96-well plates, saving time and reducing sample size."

Guava's Express Cell Surface Antibodies are a line of monoclonal antibodies specific for proteins on human hematopoetic-derived blood cells. Guava's antibodies are offered as direct conjugates to one of three different fluorescent dyes, eliminating the need for secondary staining and wash steps in the staining protocol. Developed for use with Guava's microcapillary cytometry systems, the new antibodies are available in concentrations that eliminate extra dilution steps associated with other antibodies. Guava's Express Cell Surface Antibody reagents, and its entire line of assays and systems, are further described on the company's website via the article webpage.

Larry Bruder, Guava Technologies' chief executive officer, stated, "Guava has developed the most sophisticated and robust bench top systems and assays for the drug discovery and cell biology communities. This year, we are introducing a number of new reagent lines that can allow greater scalability and efficiency of sampling, thereby reducing costs. These reagents reflect Guava's ongoing commitment to revolutionizing the way that a variety of cell-based assays are performed."

Guava Technologies' systems, including the Guava EasyCyte and EasyCyte Mini, are affordable, highly compact, microliter-scaled cell analysis systems that offer integrated, turnkey operations. Only a few microliters of samples, such as cultured and blood cells, are required for each experiment, saving precious cells and reagents and reducing potentially hazardous biological waste. These highly sensitive systems offer precise, accurate and easy-to-read results with often less than one day of training.

The Guava EasyCyte system is ideally suited for automatic, high-throughput, 96-well microplate and multiple microcentrifuge tube analysis. Well-suited for fluorescent protein analysis, the Guava EasyCyte system also allows rapid, easy screening of GFP transfectant cells. The Guava EasyCyte Mini System comes in a single-sample format and is well-suited for manual, single-sample, microcentrifuge tube analysis.

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AntibodiesAntibodies are used in techniques such as confocal and fluorescence microscopy, flow cytometry, ELISA, ELISPOT, immunohistochemistry, western blotting and immunopreciptation. Select specific antigen reactivity, high specific affinity, low non-specific binding, monoclonal or polyclonal, primary or secondary antibodies and associated conjugates such as an enzyme or dye for visualization.MicroplatesMicroplates are multi-well plates used to increase the throughput of biological investigations. The number of wells microplates contain can range from 6 to 3243 wells, with the 96-well format being the most commonly used. Microplates can come tailored for a range of applications including cell culture, PCR, filtration, storage, non-binding surface, protein crystallization, as well as pre-coated, deep well and normal Standard microplates. Additionally, options for microplate colors include clear , black, white or black with clear bottom and white with clear bottom for absorbance microplate reader applications. Find the best microplates for your lab in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.High-Throughput ScreeningHigh-throughput screening (HTS) is an automated drug discovery technique for identification of active compounds against a compound library. Use HTS readers and integrated assay preparation / analysis workstations to screen your compounds. Identify active compounds against various HTS libraries, including membranes, proteins and peptides and HTS cell lines. Find the best high-throughput screening products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Assay AssemblyAssay Assembly is technique used in drug discovery to develop assays to test the cytotoxicity, genotoxicity, or other activities of a compound on a cell. Assay assembly requires chip assembly, a delivery system and a detection and analysis method. Beneficial features of assay kits or automated systems include high-throughput, high speed and sensitivity and low signal to noise ratio.HematologyIn Haematology / Hematology, complete blood cell counts (or full blood counts) are obtained using automated blood count analyzers to enumerate blood cell types.  Hematology also encompasses haemostasis and coagulation, thrombophilia and hemophilia, plasma viscosity and ESR analysis, hemoglobinopathies, cell morphology and haematinic measurement.